TUMOR IMMUNOLOGY.pdf

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(5) Immunosuppressive cytokines • a number of immunosuppressive cytokines. • IL-10 inhibits antigen presentation and IL-12 production. • TGF-beta induces overproduction of IL-10. • VEGF (vascular endothelial growth factor), avoid immune recognition, inhibit the effector function, prevent T cell activation, cytokine production.
Page 1 and 2: Cancer Immunology and Immunotherapy
Page 3 and 4: Definitions of Cancer • Cancer co
Page 5 and 6: Neoplastic Transformation -- Carcin
Page 7 and 8: Current strategies to combat cancer
Page 9 and 10: Cancer Immunology and Immunotherapy
Page 11: Cancer Immunosurveilance • The hy
Page 14: Army of the host to fight cancers A
Page 17 and 18: Helper T cells CD4+ T cells: reacti
Page 19 and 20: Other cells NK cells: after activat
Page 21 and 22: Antibody - produced by B cells •
Page 23 and 24: How does cancer Single cancer cell
Page 25 and 26: Mechanisms of cancer escape from th
Page 27 and 28: (1) Loss/down-regulation of HLA cla
Page 29 and 30: Tumor Antigens • Altered self: K-
Page 31 and 32: T cell Activation T cell No Activat
Page 33: (4) Alterations in cell death recep
Page 37 and 38: Regulatory T Cells T cells compete
Page 39 and 40: Possible suppressive mechanisms reg
Page 41 and 42: Summary: Main defences of the tumor
Page 43 and 44: • Immune defects in T cells • M
Page 45 and 46: Tumor mass Vessel Lymphocyte FasL+
Page 47 and 48: Tumor-derived factors with DC inhib
Page 50 and 51: Activation versus suppression of im
Page 52 and 53: The defense of tumor overweighs the
Page 54 and 55: Tumor Immunotherapy Strategies to i
Page 56 and 57: Strategies to supplement the missin
Page 58 and 59: Main Mechanisms of Immunotherapy
Page 60 and 61: Current Immunotherapeutic strategie
Page 62 and 63: Antibody Therapy Rituximab: The fir
Page 64 and 65: Local and regional IL-2 administrat
Page 66 and 67: Tumor escape mechanism and T-cell a
Page 68 and 69: Antitumor Vaccines Administration o
Page 70 and 71: Antitumor Vaccines
Page 72 and 73: Dendritic Cells That Attack Cancer
Page 74: Examples from my research work
Page 77 and 78: Gene transfer of antisense hypoxia
Page 79 and 80: B7H3-meidated Cancer Immunotherapy
Page 81 and 82: Gene transfer results in expression
Page 83 and 84: Production of anti-tumor cytokine a
Page 85 and 86:
Conclusion • Immunotherapy may be
Page 87:
DR Kevin Sun Department of Molecula
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