TUMOR IMMUNOLOGY.pdf

Antibody - produced by B cells
• Direct attack: blocking growth factor receptors, arresting
proliferation of tumor cells, or inducing apoptosis.
-- is not usually sufficient to completely protect the body.
• Indirect attack: -- major protective efforts
(1) ADCC (antibody-dependent( cell mediated cytotoxicity y )
-- recruiting cells that have cytotoxicity, such as monocytes and
macrophages.
(2) CDC (complement dependent cytotoxicity)
-- binding to receptor, initiating the complement system,
'complement cascade’, resulting in a membrane attack
complex, causing cell lysis and death.
Heavy chain
Light chain
Constant region
Antigen-binding
region
Assembled antibody molecule
-- missile