Pesticide Analyzer Reference - writeframeofmind.biz

About This Manual
Analytical methods for food safety are used to screen and confirm positive pesticides results and they must be granted at least four identification points. For
LC/MS and GC/MS detection methods using either electron ionization (EI) or chemical ionization (CI), two derivatives or the powerful MSMS or HRMS
are available. For maximum productivity, the highly specific MSMS and HRMS methods are the preferred methods. Multi-residue pesticide methods are
analytically challenging because of the diverse number of chemical structures and physical properties of the target analytes.
Thermo Fisher Scientific provides methods and mass spectrometry instrumentation that complies with the strict international rules for screening and
confirmatory analyses on either LC or GC separation for polar or less polar compounds using ion trap, triple quad or high resolution accurate mass MS
instrumentation. The information and methodology in this document will show you how to analyze large numbers of pesticides using the TSQ Quantum GC
mass spectrometer.
About This Manual
Pesticide analysis is a chromatographic challenge because there is a large variety of chemical compound groups that require high sample throughput and short
run times. Sample preparation and clean-up is an integral step in pesticide analysis because there is a significant amount of sample matrix involved. Setting up
the analytical method in a particular way can cut down on instrument maintenance and increase the robustness of the method. In this manual, we will
describe how to set up a generic method for the multi-component GC-MS/MS analysis of over 500 pesticides.
This method includes information about implementing the widely distributed QuEChERS sample preparation procedure, which is suitable for non- and
low-fat sample material and can be employed for GCMS and LCMS. For GCMS extractions, an additional solvent exchange step is included in the method,
which provides the extract in a GC-compatible solvent. For LCMS, the intermediate acetonitrile extract can be used directly.
The GCMS method of choice for a multi-component pesticide analysis in matrix samples is the MS/MS technique using either ion trap or triple quadrupole
mass spectrometers. The sample preparation, GC configuration and analytical method setup information is valid for ion trap detection with PolarisQ or ITQ.
The MS part of this manual focuses on the use of the TSQ Quantum GC triple quadrupole mass spectrometer for creating a multiple reaction monitoring
(MRM) analysis method.
Thermo Scientific Pesticide Analyzer Reference 3