Protein biosynthesis: aminoacyl-tRNA synthetases and aminoacylation
Protein biosynthesis: aminoacyl-tRNA synthetases and aminoacylation
Protein biosynthesis: aminoacyl-tRNA synthetases and aminoacylation
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<strong>tRNA</strong> identity elements<br />
• signals in <strong>tRNA</strong> required by AaRSs for correct<br />
<strong>aminoacyl</strong>ation, “second genetic code”<br />
• each AaRS must be able to distinguish the correct<br />
(cognate) <strong>tRNA</strong> from all the others<br />
• isoacceptor <strong>tRNA</strong>s have mostly the same set of<br />
identity determinants<br />
• swapping identity elements between <strong>tRNA</strong>s can<br />
cause the AaRS to add amino acid to the wrong<br />
<strong>tRNA</strong><br />
• identity of <strong>tRNA</strong> is determined by its primary,<br />
secondary <strong>and</strong> tertiary structure
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