Protein biosynthesis: aminoacyl-tRNA synthetases and aminoacylation
Protein biosynthesis: aminoacyl-tRNA synthetases and aminoacylation
Protein biosynthesis: aminoacyl-tRNA synthetases and aminoacylation
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Aminoacyl-<strong>tRNA</strong> <strong>synthetases</strong><br />
(AaRS)<br />
• charge <strong>tRNA</strong>s with amino acids (establish the<br />
link between nucleic <strong>and</strong> amino acids)<br />
• divided into two unrelated classes by based on<br />
structural <strong>and</strong> biochemical properties<br />
• highly specific - join 1 type of amino acid to all its<br />
corresponding (cognate) <strong>tRNA</strong>s<br />
• nomenclature:<br />
Nomenclature of <strong>tRNA</strong> <strong>synthetases</strong> <strong>and</strong> charged <strong>tRNA</strong>s.<br />
amino<br />
acid<br />
serine<br />
leucine<br />
cognate<br />
<strong>tRNA</strong><br />
<strong>tRNA</strong> Ser<br />
<strong>tRNA</strong> Leu<br />
<strong>tRNA</strong> Leu<br />
UUA<br />
cognate <strong>aminoacyl</strong> <strong>tRNA</strong><br />
synthetase<br />
seryl-<strong>tRNA</strong> synthetase<br />
leucyl-<strong>tRNA</strong> synthetase<br />
<strong>aminoacyl</strong> <strong>tRNA</strong><br />
(charged <strong>tRNA</strong>)<br />
seryl- <strong>tRNA</strong> Ser<br />
leucyl- <strong>tRNA</strong> Leu<br />
leucyl- <strong>tRNA</strong> Leu<br />
UUA
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