synthesis and catalytic functionalization of biologically active indoles

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3724 N. Schwarz et al. PAPER Table 1 Model Reaction of Indole 13 with o-Cresol a (continued) Br N OTBDMS Me + Entry Ligand Yield (%) b 16 13 P 8 8
PAPER Coupling Reactions of Electron-Rich Indoles 3725 Table 2 Optimization of the Model Reaction of Indole 13 with o-Cresol a Br N OTBDMS Me + OH Entry Pd source Catalyst (mol%) Ligand 7 (mol%) Solvent Base Temperature (°C) Yield (%) b 16 13 1 Pd(OAc) 2 0.5 1 toluene K 3PO 4 100 25 2 Pd(OAc) 2 1 2 toluene K 3PO 4 100 34 3 Pd(OAc) 2 2 4 toluene K 3PO 4 100 75 4 Pd(OAc) 2 2 4 c toluene K 3PO 4 100 60 5 Pd(OAc) 2 2 4 toluene K 3PO 4 120 83 6 Pd(OAc) 2 2 4 toluene K 3PO 4 140 75 7 Pd(OAc) 2 2 4 toluene K 3PO 4 160 71 8 Pd 2dba 3 2 4 toluene K 3PO 4 100 44 9 Pd 2dba 3 2 4 toluene K 3PO 4 120 38 10 PdCl 2 2 4 toluene K 3PO 4 100
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Leibniz-Institut für Katalyse e. V
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Für meine Eltern Siegfried und Ker
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Mein besonderer Dank gilt Dr. Anneg
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Table of Contents Preface .........
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List of Abbreviations Ac Acetyl aq
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Preface The search for drugs is an
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1 Palladium-catalyzed Coupling Reac
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Page 97 and 98: Table 2: Reaction of N-methyl-N-phe
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Page 103 and 104: Table 2. Reaction of different amin
Page 105 and 106: 3 Publications 94 Experimental Data
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Page 119 and 120: 3 Publications 108 3.5 Synthesis of
Page 121 and 122: Scheme 2 Ti-catalyzed synthesis of
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Page 127 and 128: FULL PAPER DOI: 10.1002/ejoc.200800
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Page 139 and 140: FULL PAPER DOI: 10.1002/ejoc.200700
Page 141 and 142: Synthesis of Indole-2,3-dicarboxyla
Page 143 and 144: 3 Publications 132 3.8 Selective Re
Page 145 and 146: 8 7 N R N R OH CO2Et CO2Et OH indol
Page 147 and 148: mixture was stirred at 78 C for 3 m
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Page 151 and 152: DOI: 10.1002/cssc.200700160 General
Page 153 and 154: Zn-Catalyzed Hydroamination of Term
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4608 K. Alex et al. / Tetrahedron L
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Publikationen 1 Titanium-Catalyzed
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synthesis and catalytic functionalization of biologically active indoles

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