synthesis and catalytic functionalization of biologically active indoles

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Table of Contents IV 3.9 General Zn-Catalyzed Intermolecular Hydroamination of Terminal Alkynes................................................................................................ 139 3.10 Zn-Catalyzed Synthesis of Pyrazolines and Pyrazoles via Hydrohydrazination ............................................................................. 146 3.11 First Synthesis of 4,5-Dihydro-3(2H)-pyridazinones via Zn-mediated Hydrohydrazination ............................................................................. 150
List of Abbreviations Ac Acetyl aq Aqueous Ar Aryl BINAP 2,2´-Bis(diphenylphosphino)-1,1´-binaphthyl Bn Benzyl Boc tert-Butyloxycarbonyl Bu Butyl nBu normal-Butyl tBu tert-Butyl tBuOH tert-Butanol (tBu2) BP-phos 2-(Di-tert-butylphosphino)bi-phenyl Bz Benzoyl Cat. Catalyst Conv. Conversion Cy Cyclohexyl dba Dibenzylidene acetone DBU 1,8-Diazobicyclo [5.4.0]-undec-7-ene DCM Dichlormethane DME Dimethoxyethane DMF Dimethylformamide DMSO Dimethylsulfoxide DPEphos Bis(2-diphenylphosphinophenyl)ether dppf Bis(diphenylphosphino)ferrocen dppm Bis(diphenylphosphino)methane EOM Ethoxymethyl EWG Electron-withdrawing group equiv Equivalent Et Ethyl et al. et alii, et aliae or et alia etc. et cetera EtOH Ethanol EP Receptor for E series ofPprostaglandins GC Gas chromtography h Hour L Ligand LiHMDS Lithium hexamethyldisilazide m Meta V
Page 1 and 2: Leibniz-Institut für Katalyse e. V
Page 3 and 4: Für meine Eltern Siegfried und Ker
Page 5 and 6: Mein besonderer Dank gilt Dr. Anneg
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Page 11 and 12: Preface The search for drugs is an
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1 Palladium-catalyzed Coupling Reac
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3 Publications 3.1 Titanium-Catalyz
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1092 N. Schwarz et al. LETTER Table
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1094 N. Schwarz et al. LETTER 2,6-d
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3 Publications 84 3.2 Zinc-Promoted
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Table 2: Reaction of N-methyl-N-phe
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Am. Chem. Soc. 2002, 124, 15168 - 1
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A novel palladium catalyst for the
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Table 2. Reaction of different amin
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3 Publications 94 Experimental Data
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3 Publications 96 (q); 115.3 (d, J
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3 Publications 98 3.4 Palladium-Cat
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PAPER Coupling Reactions of Electro
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3 Publications 108 3.5 Synthesis of
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Scheme 2 Ti-catalyzed synthesis of
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mixture was used for the synthesis
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7.11 (ddd, 1H, J = 8.0 Hz, J = 7.0
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FULL PAPER DOI: 10.1002/ejoc.200800
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Synthesis of Potential 5-HT 6 Recep
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FULL PAPER DOI: 10.1002/ejoc.200700
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Synthesis of Indole-2,3-dicarboxyla
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3 Publications 132 3.8 Selective Re
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8 7 N R N R OH CO2Et CO2Et OH indol
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mixture was stirred at 78 C for 3 m
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3.89 (s, 2H, H-10), 4.27 (s, 2H, H-
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DOI: 10.1002/cssc.200700160 General
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Zn-Catalyzed Hydroamination of Term
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Zn-Catalyzed Hydroamination of Term
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3 Publications 146 3.10 Zn-Catalyze
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Over the past years, we investigate
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3 Publications 150 3.11 First Synth
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4608 K. Alex et al. / Tetrahedron L
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Publikationen 1 Titanium-Catalyzed
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