synthesis and catalytic functionalization of biologically active indoles

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3730 N. Schwarz et al. PAPER (13) (a) Moyer, M. P.; Shiurba, J. F.; Rapoport, H. J. Org. Chem. 1986, 26, 6425. (b) Taylor, E. W.; Nikam, S. S.; Lambert, G.; Martin, A. R.; Nelson, D. L. Mol. Pharmacol. 1988, 34, 42. (c) Agarwal, A.; Pearson, P. P.; Taylor, E. W.; Li, H. B.; Dahlgren, T.; Herslöf, M.; Yang, Y.; Lambert, G.; Nelson, Synthesis 2007, No. 23, 3722–3730 © Thieme Stuttgart · New York D. L.; Regan, J. W.; Martin, A. R. J. Med. Chem. 1993, 36, 4006. (d) Miao, G.; Ye, P.; Yu, L.; Baldino, C. M. J. Org. Chem. 2005, 70, 2332. (14) (a) Yang, Y.; Martin, A. R. Heterocycles 1992, 34, 1395. (b) Yang, Y.; Martin, A. R.; Nelson, D. L.; Regan, J. Heterocycles 1992, 34, 1169.
3 Publications 108 3.5 Synthesis of 3-(2-N,N-Diethylaminoethoxy)indoles as Potential 5-HT6 Receptor Ligands Karolin Alex, Nicolle Schwarz, Vivek Khedkar, Iliyas Ali Sayyed, Annegret Tillack, Dirk Michalik, Jörg Holenz, José Luis Diaz, Matthias Beller, Org. Biomol. Chem. 2008, 6, 1802-1807. Contributions: In this paper I contributed to a significant amount of the argumentation and the synthetic work. I performed synthesis of compounds 9a, 9b, 9c and 9d. My contribution as co-author of this paper is approximately 30%.
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Leibniz-Institut für Katalyse e. V
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Für meine Eltern Siegfried und Ker
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Mein besonderer Dank gilt Dr. Anneg
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Table of Contents Preface .........
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List of Abbreviations Ac Acetyl aq
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Preface The search for drugs is an
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1 Palladium-catalyzed Coupling Reac
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Page 67 and 68: 1 Palladium-catalyzed Coupling Reac
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Page 91 and 92: 1092 N. Schwarz et al. LETTER Table
Page 93 and 94: 1094 N. Schwarz et al. LETTER 2,6-d
Page 95 and 96: 3 Publications 84 3.2 Zinc-Promoted
Page 97 and 98: Table 2: Reaction of N-methyl-N-phe
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Page 103 and 104: Table 2. Reaction of different amin
Page 105 and 106: 3 Publications 94 Experimental Data
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Page 111 and 112: PAPER Coupling Reactions of Electro
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Page 121 and 122: Scheme 2 Ti-catalyzed synthesis of
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Page 125 and 126: 7.11 (ddd, 1H, J = 8.0 Hz, J = 7.0
Page 127 and 128: FULL PAPER DOI: 10.1002/ejoc.200800
Page 129 and 130: Synthesis of Potential 5-HT 6 Recep
Page 139 and 140: FULL PAPER DOI: 10.1002/ejoc.200700
Page 141 and 142: Synthesis of Indole-2,3-dicarboxyla
Page 143 and 144: 3 Publications 132 3.8 Selective Re
Page 145 and 146: 8 7 N R N R OH CO2Et CO2Et OH indol
Page 147 and 148: mixture was stirred at 78 C for 3 m
Page 149 and 150: 3.89 (s, 2H, H-10), 4.27 (s, 2H, H-
Page 151 and 152: DOI: 10.1002/cssc.200700160 General
Page 153 and 154: Zn-Catalyzed Hydroamination of Term
Page 155 and 156: Zn-Catalyzed Hydroamination of Term
Page 157 and 158: 3 Publications 146 3.10 Zn-Catalyze
Page 159 and 160: Over the past years, we investigate
Page 161 and 162: 3 Publications 150 3.11 First Synth
Page 163 and 164: 4608 K. Alex et al. / Tetrahedron L
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