synthesis and catalytic functionalization of biologically active indoles
synthesis and catalytic functionalization of biologically active indoles
synthesis and catalytic functionalization of biologically active indoles
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PAPER Coupling Reactions <strong>of</strong> Electron-Rich Indoles 3725<br />
Table 2 Optimization <strong>of</strong> the Model Reaction <strong>of</strong> Indole 13 with o-Cresol a<br />
Br<br />
N<br />
OTBDMS<br />
Me<br />
+<br />
OH<br />
Entry Pd source Catalyst (mol%) Lig<strong>and</strong> 7 (mol%) Solvent Base Temperature (°C) Yield (%) b<br />
16<br />
13<br />
1 Pd(OAc) 2 0.5 1 toluene K 3PO 4 100 25<br />
2 Pd(OAc) 2 1 2 toluene K 3PO 4 100 34<br />
3 Pd(OAc) 2 2 4 toluene K 3PO 4 100 75<br />
4 Pd(OAc) 2 2 4 c toluene K 3PO 4 100 60<br />
5 Pd(OAc) 2 2 4 toluene K 3PO 4 120 83<br />
6 Pd(OAc) 2 2 4 toluene K 3PO 4 140 75<br />
7 Pd(OAc) 2 2 4 toluene K 3PO 4 160 71<br />
8 Pd 2dba 3 2 4 toluene K 3PO 4 100 44<br />
9 Pd 2dba 3 2 4 toluene K 3PO 4 120 38<br />
10 PdCl 2 2 4 toluene K 3PO 4 100