Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
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<str<strong>on</strong>g>Fact</str<strong>on</strong>g> <str<strong>on</strong>g>Sheets</str<strong>on</strong>g> <strong>on</strong> <strong>Antiretroviral</strong> <strong>Drugs</strong><br />
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� Didanosine * can possibly decrease absorpti<strong>on</strong> of Daps<strong>on</strong>e; Itrac<strong>on</strong>azole;<br />
Ketoc<strong>on</strong>azole (separate administrati<strong>on</strong>: at least two hours before or after<br />
Didanosine).<br />
Side Effects Frequency Severity<br />
Pancreatitis # ++ �<br />
Peripheral neuropathy ++ +++<br />
Increase in liver functi<strong>on</strong> tests ++ +<br />
Diarrhoea ++ +/-<br />
Nausea ++ +/-<br />
Elevated amylase + ++<br />
Elevated lipase + +<br />
Vomiting + +/-<br />
Rash + +/-<br />
Elevated urate + +/-<br />
Headache + +/-<br />
Abdominal pain +/- +/-<br />
# The risk is increased by the c<strong>on</strong>comitant use of D4T or D4T + Hydroxyurea<br />
Lamivudine (3TC)<br />
Class<br />
Nucleoside Reverse Transcriptase Inhibitor (NRTI)<br />
Available formulati<strong>on</strong>s<br />
Storage<br />
� Oral suspensi<strong>on</strong>: 10 mg/ml<br />
� Tablets: 150, 300 mg<br />
Room temperature
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