Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
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<str<strong>on</strong>g>Fact</str<strong>on</strong>g> <str<strong>on</strong>g>Sheets</str<strong>on</strong>g> <strong>on</strong> <strong>Antiretroviral</strong> <strong>Drugs</strong><br />
Side Effects Frequency Severity<br />
Elevated CPK + +/-<br />
Elevated uric acid + +/-<br />
Dizziness + +/-<br />
C<strong>on</strong>stipati<strong>on</strong> + +/-<br />
Flatulence + +/-<br />
Bilirubinemia increase + +/-<br />
Pancreatitis +/- +++<br />
Allergic reacti<strong>on</strong>s - +++<br />
Hepatitis - +++<br />
Saquinavir (SQV)<br />
Class<br />
Protease Inhibitor (PI)<br />
Available formulati<strong>on</strong>s<br />
� Capsules: 200 mg (Hard Gelatin Capsules: Invirase®)<br />
� Capsules: 200 mg (Soft Gelatin Capsules: Fortovase®)<br />
Fortovase® soft gelatin capsules and Invirase® capsules are not bioequivalent and<br />
cannot be used interchangeably<br />
Storage<br />
Dose<br />
� HGC: Room temperature<br />
� SGC: Refrigerate; it can be kept at room temperature for up to 3 m<strong>on</strong>ths<br />
Adults (HGC and SGC): 1000 mg (5 caps.) SQV + 100 mg(1 caps.) RTV twice<br />
daily (WHO recommended)<br />
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