Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
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Interacti<strong>on</strong>s with other drugs<br />
� Rare<br />
� Stavudine levels are decreased by Methad<strong>on</strong>e.<br />
� Do not administer with Zidovudine due to antag<strong>on</strong>ism.<br />
<str<strong>on</strong>g>Fact</str<strong>on</strong>g> <str<strong>on</strong>g>Sheets</str<strong>on</strong>g> <strong>on</strong> <strong>Antiretroviral</strong> <strong>Drugs</strong><br />
Side Effects Frequency Severity<br />
Peripheral neuropathy # + or +++ +++<br />
Increase in liver enzymes +++ +<br />
Headache ++ +<br />
Pancreatitis* + �<br />
Increase in amylase + +++<br />
Increase in lipids + +<br />
Increase in urate + +/-<br />
Increase in creatine phosphokinase + +/-<br />
GI disturbances + +/-<br />
Rash + +/-<br />
# Observed in up to 24% patients with less than 50 CD4/mm 3<br />
* The risk is increased by the c<strong>on</strong>comitant use of DDI or DDI + Hydroxyurea.<br />
Zalcitabine (DDC)<br />
Class<br />
Nucleoside Reverse Transcriptase Inhibitor (NRTI)<br />
Available formulati<strong>on</strong>s<br />
Tablets: 0.375 and 0.75 mg<br />
Storage<br />
Room temperature<br />
Dose<br />
Adults: 0.75 mg (1 tab.) three times daily<br />
Children: 0.01 mg/kg every eight hours (paediatric use not approved)<br />
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