Fact Sheets on Antiretroviral Drugs

<strong>Fact</strong> <strong>Sheets</strong> on Antiretroviral Drugs
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� Contraindicated drugs (DLV not to be taken with these drugs): Alprazolam;
Astemizole; Cisapride; Ergotamine and similar alkaloids; Garlic
supplements; H-2 blockers; Lovastatin; Midazolam; proton pump
inhibitors; Rifabutin; Rifampicin; Simvastatin; St. John’s wort (hypericum
perforatum); Terfenadine and Triazolam.
� Delavirdine levels are increased by Clarithromycin and Fluoxetine.
� Delavirdine levels are decreased by Nelfinavir; Rifampicin and Rifabutin.
� Delavirdine increases levels of Amprenavir; Clarithromycin; Dapsone;
§Indinavir; Nelfinavir; Quinidine; Rifabutin; Ritonavir; §Saquinavir;
§Sildenafil and Warfarin.
� Potential interactions with anticonvulsants; statins; Methadone; oral
contraceptives; Calcium channel blockers and oral anticoagulants.
Side Effects Frequency Severity
Rash* +++ ++
Nausea ++ +/-
Severe rash* + +++
Vomiting + +/-
Elevated transaminase + +/-
Diarrhoea + +/-
Fatigue +/- +/-
Headache +/- +/-
Stevens-Johnson syndrome -
(