Fact Sheets on Antiretroviral Drugs

<strong>Fact</strong> <strong>Sheets</strong> on Antiretroviral Drugs
� Indinavir levels are increased by Clarithromycin; Delavirdine (§IDV);
Ketoconazole (§IDV); Itraconazole (§IDV); Lopinavir/r (§IDV); Nelfinavir;
Quinidine; §Ritonavir (§IDV) and Sildenafil.
� Indinavir levels are decreased by Amprenavir; Efavirenz (§IDV);
Fluconazole; Grapefruit juice; Nevirapine (§IDV); Rifampicin and
§Rifabutin (§IDV).
� Indinavir increases levels of Amprenavir; Clarithromycin; Ethinyl estradiol;
Isoniazid; Ketoconazole; Nelfinavir; Nevirapine; §Rifabutin (§IDV);
§Sildenafil; Trimethoprim and Zidovudine.
� Indinavir decreases levels of §Methadone (when IDV is given in
combination with RTV).
� Potential interactions with anticonvulsants; other statins (Pravastatin can be
used); oral contraceptives; tricyclic antidepressants; oral anticoagulants and
Amiodarone.
Side Effects Frequency Severity
Nephrolithiasis or nephrotoxicity ++ +++
Abdominal pain ++ ++
GI intolerance ++ +
Increase of indirect bilirubinaemia ++ +/-
Increase in liver function tests + ++
Neutropenia + ++
Rash + +/-
Taste perversion (metallic taste) + +/-
Headache + +/-
Asthenia + +/-
Dizziness + +/-
Thrombocytopenia + +/-
Alopecia/Hair loss + +/-
Hepatitis - ++
Page 41