Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
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Dose (WHO recommended)<br />
<str<strong>on</strong>g>Fact</str<strong>on</strong>g> <str<strong>on</strong>g>Sheets</str<strong>on</strong>g> <strong>on</strong> <strong>Antiretroviral</strong> <strong>Drugs</strong><br />
Adults: > 60 kg: 200 mg (buff. tabs.) twice daily or 250 mg (buff.<br />
powder) twice daily or 400 mg <strong>on</strong>ce daily (buff. tabs. or<br />
EC caps.)<br />
< 60 kg: 125 mg (buff. tabs.) twice daily or 167 mg (buff.<br />
powder) twice daily or 250 mg <strong>on</strong>ce daily (buff. tabs. or EC caps.)<br />
Children: < 3 m<strong>on</strong>ths: 50 mg/m 2 of body surface twice daily or 240<br />
mg/m 2 <strong>on</strong>ce daily<br />
Food effect<br />
It can be taken with or without food.<br />
Half-life in plasma<br />
From 5 to 7 hours<br />
Metabolism<br />
3 m<strong>on</strong>ths - < 13 years: 90 mg/m2 twice daily or<br />
240 mg/m2 <strong>on</strong>ce daily<br />
= 13 years or > 60 kg = adult dosage<br />
It is eliminated unchanged through renal excreti<strong>on</strong>.<br />
Interacti<strong>on</strong>s with other drugs<br />
� Rare<br />
� Trimethoprim/Sulfamethoxazole (TMP/SMX) increases Lamivudine blood<br />
levels.<br />
� Do not administer with Zalcitabine due to possible antag<strong>on</strong>ism.<br />
Side Effects Frequency Severity<br />
Headache ++ +/-<br />
Neutropenia + ++<br />
Nausea + +/-<br />
Increase in liver functi<strong>on</strong> tests + +/-<br />
Skin rash + +/-<br />
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