Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
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PROTEASE INHIBITORS (PIs)<br />
Amprenavir (APV)<br />
Class<br />
Protease Inhibitor (PI)<br />
Available formulati<strong>on</strong>s<br />
Storage<br />
� Oral suspensi<strong>on</strong>: 15 mg/ml<br />
� Capsules: 50 and 150 mg<br />
Room temperature<br />
Dose<br />
Adults: 1200 mg (8 caps.) twice daily<br />
If given with Rit<strong>on</strong>avir boosting dose:<br />
<str<strong>on</strong>g>Fact</str<strong>on</strong>g> <str<strong>on</strong>g>Sheets</str<strong>on</strong>g> <strong>on</strong> <strong>Antiretroviral</strong> <strong>Drugs</strong><br />
600 mg (4 caps.) APV + 100 mg (1 caps.) RTV twice daily<br />
1200 mg (8 caps.) APV + 200 (2 caps.) mg RTV <strong>on</strong>ce daily<br />
Children: capsules: 20 mg/kg every 12 hours or 15 mg/kg three<br />
times daily (total dosage should not exceed a total of<br />
1200 mg every 12 hours)<br />
oral soluti<strong>on</strong>: 22.5 mg/kg every 12 hours or 17 mg/kg<br />
three times daily total dosage should not exceed a<br />
total of 1400 mg every 12 hours) (see warning below)<br />
Amprenavir is 14% less bioavailable from the liquid formulati<strong>on</strong> than from the<br />
capsules; therefore Amprenavir capsules and Amprenavir oral soluti<strong>on</strong> are not<br />
interchangeable <strong>on</strong> a milligram-per-milligram basis.<br />
Food effect<br />
It can be taken with or without food; high fat meal should be avoided.<br />
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