Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
Fact Sheets on Antiretroviral Drugs
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<str<strong>on</strong>g>Fact</str<strong>on</strong>g> <str<strong>on</strong>g>Sheets</str<strong>on</strong>g> <strong>on</strong> <strong>Antiretroviral</strong> <strong>Drugs</strong><br />
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Side Effects Frequency Severity<br />
Fatigue + +/-<br />
Loss of appetite + +/-<br />
Mood disorders +/- +<br />
Diarrhoea +/- +/-<br />
Abdominal pain/cramps +/- +/-<br />
Cough +/- +/-<br />
Pancreatitis - +++<br />
Stavudine (D4T)<br />
Class<br />
Nucleoside Reverse Transcriptase Inhibitor (NRTI)<br />
Available formulati<strong>on</strong>s<br />
Storage<br />
� Oral soluti<strong>on</strong>: 1 mg/ml<br />
� Capsules: 15, 20, 30 and 40 mg<br />
Room temperature. After rec<strong>on</strong>stituti<strong>on</strong>, oral soluti<strong>on</strong> should be kept refrigerated; if<br />
so, it is stable for 30 days.<br />
Dose (WHO recommended)<br />
Adults: < 60 kg: 30 mg (1 caps.) twice dauly<br />
= 60 kg: o40 mg (1 caps.) twice daily<br />
Children: 1 mg/kg: every 12 hours (if at laeast 30 kg: same as adults)<br />
Food effect<br />
It can be taken with or without food.<br />
Half-life in plasma<br />
0.96 ± 0.26 hours
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