220-Dictionary of Pharmaceutical Medicine, 2nd Edition-Gerhard Nahler Annette Mollet-3211898352-S

180methods of s.a. are the actuarial method and the Kaplan–Meiermethod; the actuarial method assumes a constant risk within (butnot necessarily also between) each interval defining the life table,and computes cumulative survival rates for these regular time intervalsin contrast to exact times as in the Kaplan–Meier method;the K.–M. method yields therefore a (less regular) curve with steps,each step representing the time of an “event” for each subject; theadvantage of life-table a. is the possibility for calculating overall5-year survival for an entire cohort even though only one patientwas followed for 5 or more years; other methods to summarize survivalare e.g. mean/median duration of survival, direct calculationof 1- or 5-year survival rates or events per person-year.sustained release → see drug delivery.switch Change of the status of a drug from prescription only medicationto non-prescription drug (over-the-counter (OTC)drug).symptoms Subjective indicators of a disease as e.g. pain, tiredness,loss of appetite, anxiety a.s.o.; → see also signs.synergism → see effect modifiers, interaction of drugs.systematic error → see error.system-organ classes → see WHO adverse reaction terminology.system-organ-class frequency (SOC) → see WHO adverse reactionterminology.sus