Biennial Report 2005-2007 - Saha Institute of Nuclear Physics

232 Biennial Report 2005-07Chaetomorpha, Phormidium and Lyngbya. Only Catenella removed some amount 60 Co from themixture at pH 7. Chaetomorpha has the capacity of accumulating 152 Eu selectively from a mixtureof three different radionuclides and can be introduced as a good bio-reagent for separation of 152 Euradionuclide from the radioactive waste disposal sites.N Chakraborty†, AK Saha†, R Pal†, Dalia Nayak, Susanta LahiriCSD6.1.10.15 Dynamic complexation studies of metal insulin complexesInsulin is an anabolic polypeptide hormone produced in the cells of pancreas that regulates carbohydratemetabolism. It is used to treat some forms of diabetes mellitus. Insulin may be suitablefor receptor-targeted radiotherapy of malignant hepatocarcinoma. Therefore 210 At-(an α emitter)labeled insulin is currently of great interest. We have made 210 At-insulin complexation studiesand determined dynamic dissociation constant of this complex. The half-life of At-insulin complexagainst triple distilled water is 12 h and against ringer lactate solution is only 6 h. A similar studywas performed using 198 Au radiotracer. The half-life of Au-insulin complex is very high (36days).Kamalika Roy, Souvik Sen†, Susanta LahiriCSD6.1.10.16 Interaction studies of mercury with Arachin derived from Arachis hypogaeaThe amino acid residues provide the functional groups in a protein which can be potential ligandsfor a metallic cation. The major protein of groundnut, Arachin was isolated in its pure state andcharacterized using a previously established method. Results of gel electrophoresis reveal thatthe molecular weight of arachin is 21 kDa. Its interactions with various metal ions from differentdomains of the periodic table were studied using radiometric method. It was observed that at tracerconcentrations, arachin was found to interact only with no-carrier-added 197 Hg and no interactionis observed with 59 Fe, 60 Co, 137 Cs, 152 Eu, 201 Tl, and 200 Pb.Kalpita Ghosh, Kamalika Roy, Debashis Mukhopadhyay, Susanta LahiriCSD6.1.10.17 Studies on the interaction of poly(N-vinylpyrrolidone) with no-carrieradded61 Cu, 62 Zn, 66 Ga, 69 Ge and 71 As using tracer packet techniqueThe present experiment shows the selective and differential attitude of the commonly used drugexcipient polyvinylpyrrolidone (PVP) towards the mixture of no-carrier-added radionuclides of Cu,Zn, Ga, Ge, and As. The experiment is an in vivo model of PVP-metal interaction. 67 Ga iswidely used in diagnosis of bone tumors. Both 64 Cu and 67 Cu are promising radionuclides forendoradiotherapy. It is observed that Ga in acidic pH and Cu and Zn in basic pH strongly bindwith PVP. This property may be exploited further to use PVP as carrier of 66,67,68 Ga or 64,67 Cufor targeting specific organs which works in specific pH.Soumi Sarkar†, Dalia Nayak, Susanta LahiriCSD