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Difficulties with Molecular Clocks• The molecular clock does not run as smoothly asneutral theory predicts• Irregularities result from natural selection inwhich some DNA changes are favored overothers• Estimates of evolutionary divergences older thanthe fossil record have a high degree ofuncertainty• The use of multiple genes may improveestimatesCopyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings