Analysis of genome-scale count data in Bioconductor
Analysis of genome-scale count data in Bioconductor
Analysis of genome-scale count data in Bioconductor
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Natural extension to Poisson:negative b<strong>in</strong>omial model• Introduce the dispersion parameterY i ~ NB( µ i , ϕ i )• Still have mean expression levelµ i = M * λ i• M = library size, λ i = “conc” <strong>of</strong> gene DNA• Variance is a quadratic function <strong>of</strong> mean:Var( Y i ) = µ i ( 1 + µ i ϕ i )