Analysis of genome-scale count data in Bioconductor
Analysis of genome-scale count data in Bioconductor
Analysis of genome-scale count data in Bioconductor
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Consequences• Looks like dispersion is much larger for lowerabundance tags• Includ<strong>in</strong>g this <strong>in</strong> the model would decreaseability to call low abundance tags DE (butfurther <strong>in</strong>crease power for high abundancetags; is perhaps more correct)• DESeq has been designed to deal with this• edgeR will soon also <strong>in</strong>clude an option forallow<strong>in</strong>g dispersion to vary with abundance