12.07.2015 Views

Analysis of genome-scale count data in Bioconductor

Analysis of genome-scale count data in Bioconductor

Analysis of genome-scale count data in Bioconductor

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Further considerations• RNA-seq experiments: very small samplesizesbut need accurate p-values• Asymptotic tests (Score, Likelihood Ratio,Wald) not ideal• Instead: exact tests for the Poisson andNB models• Exact tests give accurate p-values <strong>in</strong> smallsample experiments

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