Conference Program - ABRF 2011 - Association of Biomolecular ...

all trained users. In addition, full service access via sample submissionis provided particularly in ICP-MS, LC/MS/MS and N-terminal proteinsequencing. Technical staff members manage the laboratory and areavailable to assist in the operation of various instruments and to analyzesamples on a fee-for-service basis. (Supported by NIH-NCRR Grant #1P20RR16457)104 Implementation of QualityManagement in Core ServiceLaboratoriesB. Hicks, T. Creavalle, J. Dickens, K. Haque,C. Raley, M.W. SmithGenetics and Genomics Group, AdvancedTechnology Program, SAIC-Frederick, NationalCancer Institute at Frederick, Frederick, MD, UnitedStatesThe Genetics and Genomics group of the Advanced TechnologyProgram of SAIC-Frederick exists to bring innovative genomic expertise,tools and analysis to NCI and the scientific community. The SequencingFacility (SF) provides next generation short read (Illumina) sequencingcapacity to investigators using a streamlined production approach.The Laboratory of Molecular Technology (LMT) offers a wide rangeof genomics core services including microarray expression analysis,miRNA analysis, long read (Roche) next generation sequencing,transgenic genotyping, Sanger sequencing, and clinical mutationdetection services to investigators from across the NIH. SF and LMT areworking together to bring online the third generation Pacific BioscienceSMRT sequencing platform. As the technology supporting thisgenomic research becomes more complex, the need for basic qualityprocesses within all aspects of the core service groups becomes critical.The Quality Management groupworks alongside members of theselabs to establish or improve processes supporting operations control(equipment, reagent and materials management), process improvement(reengineering/optimization, automation, acceptance criteria for newtechnologies and tech transfer), and quality assurance and customersupport (controlled documentation/SOPs, training, service deficienciesand continual improvement efforts). Implementation and expansion ofquality programs within unregulated environments demonstrates SAIC-Frederick’s dedication to providing the highest quality products andservices to the NIH community.105 Cornell University Life Sciences CoreLaboratories CenterG. Grills, J. VanEe, P. Schweitzer, S. Zhang,R. Williams, J. Pillardy, Q. Sun, W. Wang, Y. Li,D. Betel, T. Stelick, J. Spisak, L. Cote, R. Cameron,H. Wroblewski, B. Hover, L. Zhang, J. Mosher,Y. Xin, G. Westby, J. Busuttil, S. Monni,R. Sherwood, A.C. Ptak, W. Chen, J. McCardle,C. Bayles, J. Dela Cruz, M. Riccio, R. Bukowski,L. Ponnala, C. Myers, H. Singh, M. Howard,J. Flaherty, A. Manocchia, E. Dodge, K. Smith,C. Aquadro, A. Melnick, T. Brenna, W. Zipfel,A. Clark, A. Siepel, L. Carr, J.K.C. RoseCornell University, Ithaca, NY, United StatesThe Cornell University Life Sciences Core Laboratories Center (CLC)provides an array of genomics, proteomics, imaging and informaticsshared research resources and services to the university communityand to outside investigators. The CLC includes fee-for-service research,technology testing and development, and educational components.The Center has seven core facilities, including genomics (DNAsequencing, genotyping, and microarrays), epigenomics, proteomicsand mass spectrometry, microscopy and imaging, bioinformatics, bio-IT, and advanced technology assessment. The CLC is part of a NewYork State designated Center for Advanced Technology in Life ScienceEnterprise. The mission of the CLC is to promote research in the lifesciences with advanced technologies in a shared resource environment.Use of the CLC resources and services is steadily increasing due to thegrowth in the number and types of cores in the center, to the expansionof existing services and the implementation of new core technologies,and to the coordinated integration and synergy of services betweenthe CLC cores. Multidisciplinary support for multi-functional instrumentplatforms is implemented by integrated operations of the CLC corefacilities. Investigators are offered coordinated project consultationswith the directors and staff of all relevant cores during the design,data production and analysis phases of their projects. The CLC isinvolved in establishing and supporting multidisciplinary researchprojects that involve both intercampus initiatives and multi-institutionalcollaborations. With a concentration of advanced instrumentation andexpertise in their applications, the CLC is a key resource for life sciencesresearch.106 Searchable Core Facility Database:Building Resource BridgesB. Fleming, T. HunterVermont Genetics Network, University of Vermont,Burlington, VT, United StatesThe VGN Searchable Core Facility Database (http://vgn.uvm.edu/corefacilities) is a directory of Core Facilities primarily focused on NorthAmerica but with entries from around the world. It is a tool intendedto foster collaboration and assist cores in growing their user base andproviding networking opportunities. It is populated with Core Facilitiesthat have voluntarily listed themselves and would like to be contactedby researchers and other core facilities for potential collaborations.Benefits: Allows researchers to locate resources needed for their studies;Provides a channel for facilities to collaborate; and Facilitates cores toreach financial sustainability. Researchers are able to perform searchesonline by service offerings, location, association, and key phrases to finda facility that will best meet their needs. Information listed for individualcores include: short description of core, contact name, email, address,services offered, hyperlink to website, equipment, and date of lastrevision of information. The data can be exported to an excel readableXML file. The database currently lists 292 cores, representing 39 statesplus DC, 104 institutions, and 10 associations.107 Dartmouth Genomics SharedResourcesJ. Hamilton, H. Trask, W. Taylor, C. TomlinsonDartmouth Medical School, Norris Cotton CancerCenter, Hanover, NH, United StatesIn order to carry out an accurate diagnosis, prognosis, and/ortherapeutic assessment for a disease; high-throughput approaches toexamine the whole genome and transcriptome are now a necessity formodern research. Furthermore, to more fully understand the underlyingcauses of disease, high-throughput genomics are required to examinePoster AbstractsABRF 2011 — Technologies to Enable Personalized Medicine • 61