Hypoglycaemia in Clinical Diabetes

Table 3.1 Frequency of mild hypoglycaemia in adults with type 1 diabetesAuthorsNumber ofpatients Follow-up a Treatment b cHbA 1c (%)Definition ofhypoglycaemiaFrequency d(number/pt/yr)Pramming et al., 1991 411 1 week (P) 78% twice daily 87 Symptomatic 94Janssen et al., 2000 31 6 weeks (P) All multiple 72 BG < 35 mmol/l 160Pedersen-Bjergaard 201 1 week (R) 86% multiple 86 Symptomatic 104et al., 2001Pedersen-Bjergaard 170 12 months (P) 87% ≥ 4 inj 84 Symptomatic 88et al., 2003aPedersen-Bjergaard 1076 1 week (R) 72% multiple 86 Symptomatic 104et al., 2004Donnelly et al., 2005 94 4 weeks (P) 49% S&I f 83 Symptomatic 42Leckie et al., 2005 243 (27 T2) e 12 months (P) 80% multiple 91 Symptomatic 8UK HypoglycaemiaStudy Group, 200746 (< 5 yrs)54 (> 15 yrs)9–12 months All ≥ 2 injections 73 Symptomatic and/orBG < 30 mmol/l3578 29This table does not include early studies which tended to focus on rates of mild hypoglycaemia in particular subsets of patients, e.g. with impaired awareness of hypoglycaemia or individuals usingporcine versus human insulin.a Duration of follow-up: P = prospective estimation of hypoglycaemia frequency; R = retrospective.b Multiple refers to preprandial injections (inj) of soluble (or analogue) insulin and bedtime isophane insulin.c Mean HbA1c for the subjects under study.d Frequency of hypoglycaemia in each study has been adjusted to represent an annual rate per person.e 27 Patients in this study had type 2 diabetesf Patients were on soluble and isophane insulins, but frequency of injections not specified.BG = capillary blood glucose concentration.