WOMEN 'S HEALTH AND MENOPAUSE : - National Heart, Lung ...

• There is no clinical trial evidence that estrogen
improves symptoms or delays symptomatic
progression in women with Alzheimer’s disease.
• There are no published long-term clinical
trial data on potential effects of HRT on ageassociated
cognitive decline.
• One clinical trial found that vitamin E slows
progression without improving cognition
in patients with moderate dementia due to
Alzheimer’s Disease.
• One clinical trial of antihypertensive medication
in cognitively intact older adults with hypertension
showed a small but significant difference
in the rate of memory loss and the incidence of
dementia in those on active treatment.
• One clinical trial found raloxifene was associated
with less cognitive decline in two cognitive
function tests in older women.
6.2.4 Complementary and Alternative Therapies
• There is limited trial evidence that gingko biloba
may offer mild cognitive benefit when given
to patients with dementia.
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7. CONCLUSIONS
In the last 20 years, menopause has become a
household word, with much better understanding
of its consequences. The growing numbers of
postmenopausal women and clinical trials have
coincided to draw increasing attention to the perimenopausal
and postmenopausal years. Better
studies of older therapies and the expanded number
of new choices today, with more in development
and evaluation, have complicated provider and
patient choices, but greatly improved the potential
for effective intervention.