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Petra Prinz, Ainhoa-Marie Figel, Judith Hosse, Peter J Nelson, Julia S Schleypen, Nicole Baur, Dolores J Schendel, Christine S Falk, Elfriede Noessner NK cells with distinct phenotypic and functional profile in the context of myeloid infiltration and renal cell carcinoma milieu Renal cell carcinoma (RCC) harbor high numbers of infiltrating lymphocytes with apparent limited efficacy in tumor control. Two groups of clear cell RCC were identified, one containing high (>20% of the lymphocyte population, n=14), the other low (
Rachel Thomas, Maren Mönkemeyer, Gamze Kabalak, Reinhold E. Schmidt, Torsten Witte NKG2D polymorphism associated with reactivation of CMV in HIV-1 infected patients Background NKG2D is an activating C-type lectin-like receptor expressed on NK cells and cytotoxic T lymphocytes. Upon ligand binding (ligands: stress-inducible MICA/B, ULBPs) NKG2D signals via the associated DAP10 adaptor protein, inducing cytotoxicity in NK cells and co-stimulation of the TCR. The two alleles of NKG2D differ by one nucleotide, guanine (G) or adenine (A), which results in an amino acid residue substitution in the transmembrane region at the binding site to DAP10. One of these alleles may be less functionally efficient in costimulating the TCR, and is associated with SLE, Sjögren`s syndrome and scleroderma. The aim of this study is to investigate any association of these alleles with HIV and CMV. Methods PCR and RFLP analyses were used to determine the allelic distribution of NKG2D in 240 HIV patients and 239 healthy controls (all Caucasian). Fisher’s exact test was used to calculate the significance of the association. Results The A allele of NKG2D was found to be associated with HIV (with a frequency of 36% in HIV patients, 27% in healthy controls), as well as with CMV reactivation in HIV patients (48%). Associations with other co-infections (including GBV-C and HCV) have yet to be determined. Conclusions This study is investigating the importance of NKG2D signalling in HIV and CMV infections. The NKG2D-mediated control of CMV infection in HIV co-infected patients appears to play an important role, as the functionally less efficient allele is correlated with CMV reactivation. Supported by BMBF KN Rheuma C2.12
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Abstracts (complete list) Luciana B
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Angelika Stöcklinger Ablation of E
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Analysis of TCR-mediated MAPK activ
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Blockade of natural killer cell-med
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Characterization of versatile CD8 m
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Tanja Nicole Hartmann, Bretton Summ
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Marcel Andre Krüger, Kathrin Koppl
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Efficient development of Plasmodium
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Cornelia Rosner, Lutz Walter Functi
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HO-1 up-regulation increases the nu
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Anne Schumacher, Paul Ojiambo Waful
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Joachim Heinrich Maxeiner, Kerstin
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Investigation of allorestricted pep
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Milan Popovic, Ana Teles, Catharina
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Mycobacterial Lipopeptides Elicit C
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Pathogenic Trypanosoma cruzi intera
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Bettina Tosetti, Eva Glowalla, Mart
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Role of direct versus cross-present
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Max von Holleben, Simone Klöter, B
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Christof Iking-Konert, Tim Vogl, Ma
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The importance of adhesion and migr
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Marina Scheler, Manuela Brenk, Hele
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Patricia Bach, Elisabeth Kamphuis,
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Natalia Zietara, Marcin Lyszkiewicz
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Hans KUENG, Victoria LEB, Daniela H
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Frank Autschbach, Felix Lasitschka,
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Manuela Brenk, Marina Scheler, Hele
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Andreas Brandl, Juergen Wittmann, M
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Alexia Nass, Hans-Willi Mittruecker
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Stefanie Kunz, Karin Oberle, Anna S
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Annabelle Schnaith, Sonja A. Leggio
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Heribert Appelhans, Michael Walther
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Andreas Oliver Weinzierl, Dominik M
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Nousheen Zaidi, Timo Herrmann, Dani
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Elisa Kieback, Jehad Charo, Daniel
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Iris Watermann, Jeannette Gerspach,
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Peggy Riese, Thomas Ebensen, Claudi
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Mathias Konstandin, Guido Wabnitz,
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Angelika Stöcklinger Ablation of E
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Jasmin Herz, Julian Pardo, Hamid Ka
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Milena Josefina Tosiek, Marcus Gere
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Alexei Gratchev, Julia Kzhyshkowska
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Luisa Cervantes-Barragan, Ulrich Ka
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Hans-Heinrich Oberg, Jan Lenke, Sus
Page 723 and 724:
Ana Teles, Catharina Thuere, Milan
Page 725 and 726:
Yuriy Shebzukhov, Sergei Grivenniko
Page 727 and 728:
Annette Busch, Thomas Quast, Waldem
Page 729 and 730:
Volker Storn, Karsten Mahnke, Sonja
Page 731 and 732:
Claudia Stühler, Sarah Lurati, Man
Page 733 and 734:
Anna-Maria Herr, Olivia Sövegjarto
Page 735 and 736:
Jenny Pahne, Subramanya Hegde, Nadi
Page 737 and 738:
Christoph D. Brenner, Susan King, I
Page 739 and 740:
Christian Wahl, Petra Bochtler, Rei
Page 741 and 742:
Susanne Rauchmann, Karin Knieke, Ma
Page 743 and 744:
Sonja Textor, Rosita Accardi, Matth
Page 745 and 746:
Meike Winter, Roel Schins, Irmgard
Page 747 and 748:
Emmanuel Prodhomme, Claude Muller V
Page 749 and 750:
Beatrice Bolinger, Philippe Krebs,
Page 751 and 752:
Dennis Lindau, Dagmar Sigurdardotti
Page 753 and 754:
Jessica Nickel, Birgit Löer, Reinh
Page 755 and 756:
Isabel Koch, Reinhard Hoffmann Yers
Page 757:
Laura Kahmann, Sabine Warmuth, Birg
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