Abstracts (complete list) - Wissenschaft Online

Inna Lavrik, Alexander Golks, Dirk Brenner, Julia Hoffmann, Carina Pforr, Peter
Krammer
The role of new c-FLIP proteins in life and death of the T cell.
C-FLIP, also known as FLAME-1/I-FLICE/CASPER/CASH/MRIT/CLARP/Usurpin, is a welldescribed
inhibitor of death receptor-mediated apoptosis. Until present only two
isoforms of c-FLIP: c-FLIPL and c-FLIPS, were found to be expressed at the protein
level. In our studies, we found two new protein products of c–FLIP: p25-FLIP, which
turned out to be the third c-FLIP isoform, c-FLIPR; and p22-FLIP, which was shown to
be a c-FLIP N-terminal cleavage product. Both new c-FLIP proteins block caspase-8
activation at the DISC and death receptor-induced apoptosis. In addition, p22-FLIP was
shown to play a prominent role in NF-kappa B activation via interaction with the IKK
complex. Recently, we developed new insight into the mechanism of c-FLIP-mediated
NF-kappa B induction. Our new findings and the role of c-FLIP proteins in life and death
of T cells are going to be discussed.