Abstracts (complete list) - Wissenschaft Online

Aysefa Doganci, Petra Scholtes, Joachim Maxeiner, Roman Karwot, Edgar Schmitt,
Hans A. Lehr, I.Cheng Ho, Susetta Finotto
The IL-2R alpha and IL-2R beta chains differentially regulated
allergic airway inflammation in an experimental in vivo model
To assess the role of IL-2 signal transduction in experimental asthma, we compared the
effect of intranasal blockade of the IL-2Rα or β-chains. In our studies, local blockade of
the IL-2Rβ-chain, led to an amelioration of airway resistance and inflammation in OVA
sensitized and challenged mice. Moreover, both treatements led to a marked reduction
of Th2 type cytokines IL-4, IL-5 while IL-13 was inhibited specifically by the blockade of
the IL-2Rβ-chain. Consistent with these findings, blockade of the IL-2Rβ-chain, as
opposed to blockade of the IL-2Rα chain, led to a suppression of CD4+ T cells
proliferation in the local draining lymph nodes where immunosuppressive CD4+CD25+
T regulatory cells were downregulated specifically only by the IL-2Rα blockade. Taken
together these results suggest that local blockade of the IL-2Rβ-chain during the
antigen challenge phase could be a successful therapy in allergic disease by rescuing
the T regulatory cells in the local draining lymph nodes where they regulate the
development of pathogenic Th2 cells in this experimental model of asthma.
This work is supported by SFB 548 Grand.