HIV/AIDS Treatment and Care : Clinical protocols for the European ...

ManageMent of Hepatitis C and HiV CoinfeCtion
1.3.4. Other comorbidities and co-conditions
Testing of comorbidities should include a comprehensive history with a particular focus on factors
associated with more progressive liver injury. Analysis can include:
• testing for viral liver diseases 4
• testing for tuberculosis (TB) and sexually transmitted infections (STIs) that need treatment before
HCV treatment begins. 5
When a treatment has been decided, other tests are needed:
• thyroid-stimulating hormone (TSH) dosage;
• dosage of antiperoxydase, antinuclear, anti-smooth muscle, anti-liver-kidney microsome antibody
(LKM1);
• creatininaemia;
• proteinuria ;
• glycaemia;
• ferritinaemia;
• electrocardiogram (ECG, to detect coronary disease that could decompensate after treatmentinduced
anaemia);
• a pregnancy test. 6
4 For HBV and HAV please refer to Protocol 7, Management of hepatitis B and HIV coinfection.
5 See Protocol 4, Management of tuberculosis and HIV coinfection, and the European STD Guidelines (46).
6 It should be explained that because RBV is teratogenic and contraindicated during pregnancy, procreation should be avoided
during treatment and six months after, and that due to higher levels of HCV viraemia in coinfected women, approximately
20% transmit HCV to their offspring, versus 7–8% in those monoinfected with hepatitis C (47).
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