Gene Variant Report issued

Lifestyle Genomics Research Centre Ltd. 

Plymouth Science Park, 1 Davy Road, Derriford, Plymouth, PL6 8BX , UNITED KINGDOM 

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SAMPLE PROCESSED BY: 

METHOD: 

DATA CHECKED FOR ACCURACY BY: 

Genome Centre at BARTS and The London School of Medicine and Dentistry 

Fluidigm TaqMan probe-based SNP genotyping / Illumina MiSeq, Next Generation 

sequencing 


NOTES: 

genotype has no risk alleles 

genotype has one risk allele 

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genotype has two risk allels 

either allele can be a risk or be 

beneficial 

Ctr+F to activate Search Engine: Look up genes, rsids, pathways / traits 

SNP RSID INTERPRET ☞ PARENT GENE & VARIANT ⚛ CATEGORY ☤ / PATHWAY ⥹ RISK ALLELES !! cp00035774 

rs1229984 rs1229984 ADH1B Chemoprotection / Alcohol Metabolism TT CC 

rs6413413 rs6413413 ADH1B A178T Chemoprotection / Alcohol Metabolism AA TT 

rs2066702 rs2066702 ADH1B A396C Chemoprotection / Alcohol Metabolism AA CC 

rs671 rs671 ALDH2 Chemoprotection / Alcohol Metabolism AA GG 

rs2238151 rs2238151 ALDH2 Chemoprotection / Alcohol Metabolism TT CC 

rs72547566 ALDH3A2 Chemoprotection / Alcohol Metabolism TT CC 

rs1523127 rs1523127 PXR Chemoprotection / Bile Flow CC AA 

rs2547231 rs2547231 SULT2A1 Chemoprotection / Bile Flow AA CA 

rs1544410 rs1544410 VDR Bsm1 Chemoprotection / Bile Flow TT TT 

rs8007267 rs8007267 GCH1 C36378991T Chemoprotection / Biopterin TT CT 

rs10483639 rs10483639 GCH1 G55306457C Chemoprotection / Biopterin CC GC 

rs7216389 rs7216389 GSDMB Chemoprotection / Cell Danger Response TT CT 

rs8192678 rs8192678 PPARGC1A Chemoprotection / Detox TT CT 

rs1799814 rs1799814 CYP1A1*4 C2453A Chemoprotection / Detox I TT GG 

rs2472304 rs2472304 CYP1A2 Chemoprotection / Detox I AA GA 

rs2470893 rs2470893 CYP1A2 Chemoprotection / Detox I TT CC 

rs2472304 rs2472304 CYP1A2*1F Chemoprotection / Detox I AA GA



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs762551 rs762551 CYP1A2*1F C164A Chemoprotection / Detox I CC CA 

rs1056836 Hydroxylation of Estrogens CYP1B1 L432V Chemoprotection / Detox I CC GG 

rs1800440 

Estrogen Metabolism. Converts 

estradiol to 4-OH-estradiol 

CYP1B1 N453S Chemoprotection / Detox I TT TC 

rs9282671 Hydroxylation of Estrogens CYP1B1 T241A Chemoprotection / Detox I AA AA 

rs1801272 

Xenobiotics, nicotine, drugs 

metabolism. Works with CYP2B6 

CYP2A6*2 A1799T Chemoprotection / Detox I TT AA 

rs6583954 rs6583954 CYP2C19 Chemoprotection / Detox I TT CC 

rs4986894 rs4986894 CYP2C19 T98C Chemoprotection / Detox I TT TT 

rs41291556 rs41291556 CYP2C19*8 T358C Chemoprotection / Detox I CC TT 

rs2185570 rs2185570 CYP2C9 Chemoprotection / Detox I CC TT 

rs28371685 rs28371685 CYP2C9 Chemoprotection / Detox I TT CC 

rs9332239 rs9332239 CYP2C9*12 1465C>T Chemoprotection / Detox I TT CC 

rs1799853 rs1799853 CYP2C9*2 Chemoprotection / Detox I CT CC 

rs1057910 rs1057910 CYP2C9*3 Chemoprotection / Detox I CC AC 

rs9332131 rs9332131 CYP2C9*6 818delA Chemoprotection / Detox I DD AA 

rs7900194 rs7900194 CYP2C9*8 Chemoprotection / Detox I AA GG



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs28371706 rs28371706 CYP2D6*17 T107I Chemoprotection / Detox I AA GG 

rs5030867 rs5030867 CYP2D6*7 Chemoprotection / Detox I GG TT 

rs2740574 

Androgens, Xenobiotics, drugs 

metabolism, testosterone oxidation. 

CYP3A4*1B A392G Chemoprotection / Detox I GG TT 

rs3741049 rs3741049 ACAT1 G22670A Chemoprotection / Detox II AA GG 

rs2273684 rs2273684 GSS Chemoprotection / Detox II TT GG 

rs6088659 rs6088659 GSS A5997G Chemoprotection / Detox II TT CC 

rs1138272 rs1138272 GSTP1 Chemoprotection / Detox II TT CC 

rs1695 rs1695 GSTP1 Chemoprotection / Detox II GG AA 

rs1799929 rs1799929 NAT2 Chemoprotection / Detox II TT TT 

rs1208 rs1208 NAT2 Chemoprotection / Detox II GG GG 

rs1799930 rs1799930 NAT2 Chemoprotection / Detox II AA GG 

rs1801279 rs1801279 NAT2 Chemoprotection / Detox II AA GG 

rs1041983 rs1041983 NAT2 Chemoprotection / Detox II TT CC 

rs35652124 rs35652124 NFE2L2 or NRF2 Chemoprotection / Detox II TT TC 

rs1962142 rs1962142 NFE2L2 or NRF2 Chemoprotection / Detox II AA GG 

rs6726395 rs6726395 NFE2L2 or NRF2 Chemoprotection / Detox II AA AG



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs887829 rs887829 UGT1A1 Chemoprotection / Detox II TT CC 

rs3755319 rs3755319 UGT1A1 Chemoprotection / Detox II AA AC 

rs6742078 rs6742078 UGT1A1 G179250T Chemoprotection / Detox II TT GG 

rs4148323 rs4148323 UGT1A1 G211A Chemoprotection / Detox II AA GG 

rs1523127 rs1523127 PXR Chemoprotection / Detox II & III CC AA 

rs2062541 rs2062541 ABCC1 / MRP1 Chemoprotection / Detox III AA GG 

rs4148382 rs4148382 ABCC1 / MRP1 Chemoprotection / Detox III AA GG 

rs246240 rs246240 ABCC1 / MRP1 Chemoprotection / Detox III GG AG 

rs2273697 rs2273697 ABCC2 Chemoprotection / Detox III AA GG 

rs8187710 rs8187710 ABCC2 Chemoprotection / Detox III AA GG 

rs717620 rs717620 ABCC2 Chemoprotection / Detox III TT CC 

rs1405655 rs1405655 LXR Chemoprotection / Detox III TT TT 

rs17373080 rs17373080 LXR Chemoprotection / Detox III GG CC 

rs2695121 rs2695121 LXR Chemoprotection / Detox III TT CC 

rs3741049 rs3741049 ACAT1 G22670A Chemoprotection / Detox III / Bile Flow AA GG 

rs3733890 rs3733890 BHMT Chemoprotection / Detox III / Bile Flow AA GG 

rs7946 rs7946 PEMT Chemoprotection / Detox III / Bile Flow TT TT



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs4244593 rs4244593 PEMT Chemoprotection / Detox III / Bile Flow TT GG 

rs7529229 rs7529229 IL6R Chemoprotection / Immune Factor CC TC 

rs7946 rs7946 PEMT Chemoprotection / Membranes health TT TT 

rs4244593 rs4244593 PEMT Chemoprotection / Membranes health TT GG 

rs429358 rs429358 APOE Chemoprotection / Oxidative Stress CC TT 

rs7412 rs7412 APOE Chemoprotection / Oxidative Stress CC CC 

rs769217 rs769217 CAT Chemoprotection / Oxidative Stress TT CT 

rs2300181 rs2300181 CAT C21068T Chemoprotection / Oxidative Stress TT CC 

rs4626565 

Last enzyme in Electron Transport 

Chain. ROS (Reactive Oxygen 

COX6C Chemoprotection / Oxidative Stress CC TT 

Species) scavenging. 

rs1050829 rs1050829 G6PD Chemoprotection / Oxidative Stress CC TT 

rs5030868 rs5030868 G6PD Chemoprotection / Oxidative Stress AA GG 

rs5030868 rs5030868 G6PD Chemoprotection / Oxidative Stress TT GG 

rs1050828 rs1050828 G6PD Chemoprotection / Oxidative Stress AA CC 

rs1050828 rs1050828 G6PD Chemoprotection / Oxidative Stress TT CC 

rs1050450 rs1050450 GPX1 Chemoprotection / Oxidative Stress AA GA



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs2551715 Oxidised Glutathione reduction GSR Chemoprotection / Oxidative Stress TT CC 

rs1799836 rs1799836 MAOB Chemoprotection / Oxidative Stress TT TC 

rs35652124 rs35652124 NFE2L2 or NRF2 Chemoprotection / Oxidative Stress TT TC 

rs1962142 rs1962142 NFE2L2 or NRF2 Chemoprotection / Oxidative Stress AA GG 

rs6726395 rs6726395 NFE2L2 or NRF2 Chemoprotection / Oxidative Stress AA AG 

rs1800566 rs1800566 NQO1 Chemoprotection / Oxidative Stress AA GG 

rs854571 rs854571 PON1 Chemoprotection / Oxidative Stress TT TC 

rs662 rs662 PON1 Q192R Chemoprotection / Oxidative Stress TT CC 

rs4880 rs4880 SOD2 Chemoprotection / Oxidative Stress GG GG 

rs2069840 rs2069840 IL6 

Chemoprotection / Oxidative Stress / 

Immune Factor 

GG 

CC 

rs9282861 rs9282861 SULT1A1 Chemoprotection / Sulfonation CC CC 

rs182420 rs182420 SULT2A1 Chemoprotection / Sulfonation CC CT 

rs2547231 rs2547231 SULT2A1 Chemoprotection / Sulfonation AA CA 

rs11605924 

A (major) = Reduction in energy 

utilisation in a high fat diet. 

CRY2 Diet & Nutrition AA AA 

rs602662 rs602662 FUT2 Diet & Nutrition / B12 Status AA GG



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs1801198 rs1801198 TCN2 Diet & Nutrition / B12 transport GG GC 

rs9606756 rs9606756 TCN2 Diet & Nutrition / B12 transport GG AA 

rs4148211 

rs708272 

The G (minor) allele is associated 

with: Increased total cholesterol 

levels Increased levels of LDL 

cholesterol but Decreased risk of 

developing type 2 diabetesThe A 

(major) allele is associated with: 

Increased levels of triglycerides 

(AA).Low levels of LDL cholesterol 

(AA).but Increased risk of 

developing type 2 diabetes (AA). 

The “C” (major) allele is associated 

with decreased levels of HDL (good 

cholesterol).The “A” allele is 

associated with increased HDL 

levels. 

ABCG8 Diet & Nutrition / Cholesterol Status GG AA 

CETP Diet & Nutrition / Cholesterol Status GG GG



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs3213445 

The Minor "C" allele is associated 

with:Carriers of the rare allele had 

significantly higher glutamyl 

transpeptidase (GGT), glutamic 

oxaloacetic transaminase (GOT) and 

glutamic pyruvate transaminase 

(GPT) activities.A higher fatty liver 

index.Triglycerides and fasting 

CPT1A Diet & Nutrition / Cholesterol Status CC TT 

glucose were significantly higher in 

C allele carriers.Insulin sensitivity 

was lower in C allele carriers.Total 

cholesterol and LDL-cholesterol 

tended to be higher in C allele 

carriers. 

rs174548 Diet & Nutrition / Cholesterol Status FADS1 Diet & Nutrition / Cholesterol Status GG CG 

rs482548 

(TT) Lower than common level of 

FADS enzyme activity. 

FADS2 Diet & Nutrition / Cholesterol Status TT CT



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs1535 

The Minor “G” allele is associated 

with:Decrease of Docosahexaenoic 

acid (DHA) (GG) . DHA is a type of 

omega-3, which is the primary 

component of a brain cell. The 

decreased ability transform fatty 

acids into Docosahexaenoic acid 

(DHA) results in a lower IQ for nonbreast 

fed children. Breast milk 

contains usable DHA.Some studies 

have shown that breastfed children 

with the GG genotype had the same 

IQs as the AG genotype. Both 

resulting in an average IQ in low the 

100s. While Non-breastfed children 

had IQs in the upper 90s.Low levels 

of High-density Lipoprotein 

Cholesterol (HDL-C) Moderately 

increases the risk for Type-2 

Diabetes.Intensive lifestyle 

FADS2 Diet & Nutrition / Cholesterol Status GG AG



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs4846914 

The A (minor) allele is associated 

with increased levels of HDL 

cholesterol (good cholesterol) but 

GALNT2 Diet & Nutrition / Cholesterol Status GG GA 

also is associated with higher risk of 

hypertriglyceridemia. 

rs1800961 rs1800961 HNF4A Diet & Nutrition / Cholesterol Status TT CC 

rs1884614 rs1884614 HNF4A Diet & Nutrition / Cholesterol Status TT CC 

rs17700633 

The Minor "A" allele is associated 

with decreased HDL cholesterol . 

The G (major) allele is associated 

with increased HDL cholesterol. 

MC4R Diet & Nutrition / Cholesterol Status AA GA 

rs2229616 

The C (major) allele is associated 

with decreased HDL cholesterol 

levels. 

MC4R Diet & Nutrition / Cholesterol Status CC CC



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs174537 


with increased LDL cholesterol (bad 

cholesterol) levels.The T (minor) 

allele is associated with decreased 

LDL cholesterol (bad cholesterol) 

levels. 

MYRF Diet & Nutrition / Cholesterol Status GG GT 

rs7946 rs7946 PEMT Diet & Nutrition / Cholesterol Status TT TT 

rs2016520 

The T (major) allele is associated 

with increased cholesterol levels. 

PPARD Diet & Nutrition / Cholesterol Status TT TT 

rs8192678 rs8192678 PPARGC1A Diet & Nutrition / Cholesterol Status TT CT 

rs646776 

The C (minor) allele is associated 

with increased levels of LDL (bad 

cholesterol). 

PSRC1 Diet & Nutrition / Cholesterol Status CC TT



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs659366 

The "T" (minor) allele is associated 

with:More UCP2 production and 

higher levels of UCP2 protein 

Increased levels of HDL-Cholestrol 

and decreased levels of LDL- 

Cholestrol in a Chinese population. 

Reduced LDL particle size levels in a 

Chinese population.Increased 

energy expenditure.Decreased lipid 

oxidation Decreased high-sensitivity 

Cholesterol reactive protein (hs- 

CRP), a biomarker of inflammation. 

This decrease may indicate a lower 

level of inflammation in the body. 

More difficulty in losing weight 

under a very low-calorie program in 

Korean women.Higher fasting 

glucose levels in the blood.Higher 

risk of Diabetes (Type 2).Increased 

hardening of the arteries in women. 

UCP2 Diet & Nutrition / Cholesterol Status CC CT



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs2073658 

The T (minor) allele is associated 

with increased LDL cholesterol. 

USF1 Diet & Nutrition / Cholesterol Status TT CC 

rs3733890 rs3733890 BHMT Diet & Nutrition / Choline Status GG GG 

rs2236225 

G = Decreased risk of choline 

deficiency. 

MTHFD1 Diet & Nutrition / Choline Status AA GA 

rs1805087 rs1805087 MTR Diet & Nutrition / Choline Status GG AA 

rs738409 

C = Decreased need for choline in 

the body. 

PNPLA3 Diet & Nutrition / Choline Status GG CC 

rs738409 

T (minor) = higher risk of fatty liver - 

encourage more Choline.Whites 

with fatty liver - which may be due 

to low choline - were more likely to 

carry the T allele. 

PNPLA3 Diet & Nutrition / Choline Status TT CC



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs662799 

The G (minor) presumably reduces 

levels of APOA5 protein. 

Associations of APOA5 transcripts 

with PPARA and CPT1A1 transcripts 

suggest that APOA5 expression is 

intimately linked to hepatic lipid 

metabolism. 


with: 

Each G=higher tryglycerides 

AG causes 1.4x higher early heart 

attack risk 

AG causes less weight gain on high 

fat diets 

GG causes 2x higher early heart 

attack risk 

GG causes less weight gain on high 

fat diets 

APOA5 Diet & Nutrition / Fat Breakdown GG AA



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs1800562 rs1800562 HFE Diet & Nutrition / Iron Status AA GG 

rs1800562 rs1800562 HFE Diet & Nutrition / Iron Status AA GG 

rs1799945 rs1799945 HFE Diet & Nutrition / Iron Status GG CG 

rs6918586 rs6918586 HFE Diet & Nutrition / Iron Status TT CC 

rs3811647 

A = Increased Iron levels in the 

blood. 

TF Diet & Nutrition / Iron Status AA GG 

rs855791 A = Increased iron levels in blood. TMPRSS6 Diet & Nutrition / Iron Status AA GG 

rs4988235 

MCM6 has influence on the lactase 

LCT gene, rs182549 and is one of 

two SNPs that is associated with the 

primary haplotype associated with 

hypolactasia, more commonly 

known as lactose intolerance in 

European Caucasian populations. 

AA = Can digest milk .AG = Likely to 

be able to digest milk as an adult. 

GG = Likely lactose intolerant. 

MCM6 Diet & Nutrition / Lactose Tolerance GG AA



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs17300539 

rs174537 


with:Worse response to 

monounsaturated fat intake.GG = 

Higher BMI with increased 

monounsaturated fat intake (avoid 

monounsaturated fats) 


with:Possible decreased need for 

fish oil supplements to maintain 

healthy omega-3 fatty acid 

levelsIncreased levels of arachidonic 

acid in the body [R]. Arachidonic 

acid is an Omega-6 polyunsaturated 

fatty acid.TT = Possible increased 

need for fish oil supplements to 

maintain healthy omega-3 fatty acid 

levels.TT = Lower levels of 

arachidonic acid in the body. 

Arachidonic acid is an Omega-6 

polyunsaturated fatty acid. 

ADIPOQ Diet & Nutrition / Monounsaturated Fat GG GG 

MYRF Diet & Nutrition / Omega fatty acids TT GT



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METHOD: 




sequencing 


NOTES: 






beneficial 



rs894160 

rs1799986 

CC (major) =does worse with a high 

complex carb diet with regard to 

weight.People with the "T" or minor 

allele do better with complex carbs 

and worse with saturated fat. The T 

allele helps protects from weight 

gain from a higher complex carb 

diet, but causes weight gain on a 

lower carb complex carb diet and 

insulin resistance on a higher 

saturated fat diet. 

The C (major) does better with 

saturated fat (decreased weight 

gain)The AG genotype is associated 

with normal saturated fat levels. 

PLIN1 

Diet & Nutrition / Response to 

Carbohydrates 

LRP1 Diet & Nutrition / Saturated Fat TT CC 

rs744166 rs744166 STAT3 Diet & Nutrition / Saturated Fat GG AA 

rs8069645 rs8069645 STAT3 Diet & Nutrition / Saturated Fat GG AA 

rs651821 

TT = Decreased triglyceride levels. 

CC = Higher triglycerides. 

APOA5 Diet & Nutrition / Triglyceride Status CC TT 

CC 

CC


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METHOD: 




sequencing 


NOTES: 






beneficial 



rs3135506 

rs2072560 

rs2075291 

GG = Decreased triglyceride levels. 

CC = 34% Increase in triglyceride 

concentration. 

C = Lower levels of triglycerides.T = 

Higher levels of triglycerides. 

CC = Decreased risk of high 

triglyceride levels.AA = Greater than 

4x the risk for high triglyceride 

levels (n=Asian populations) AC = 4x 

higher risk for high triglyceride 

levels (n=Asian populations). 

APOA5 Diet & Nutrition / Triglyceride Status CC GG 

APOA5 Diet & Nutrition / Triglyceride Status TT CC 

APOA5 Diet & Nutrition / Triglyceride Status AA CC 

rs2266788 A = Decreased triglyceride levels. APOA5 Diet & Nutrition / Triglyceride Status GG AA




METHOD: 




sequencing 


NOTES: 






beneficial 



rs662799 







metabolism. 


with: 



attack risk 


fat diets 


attack risk 


fat diets 

APOA5 Diet & Nutrition / Triglyceride Status GG AA




METHOD: 




sequencing 


NOTES: 






beneficial 



rs3213445 

rs174570 

rs13223993 

T = Decreased triglyceride levels. 

Triglycerides and fasting glucose 

were significantly higher in C allele 

carriers. 

CC = Normal levels of triglycerides. 

TT = Increased triglycerides.CT = 

Increased triglycerides. 

A = Increased triglyceride levelsG = 

Decreased triglycerides and 

increased HDL, lowering the risk of 

cardiovascular disease and obesity. 

CPT1A Diet & Nutrition / Triglyceride Status CC TT 

FADS2 Diet & Nutrition / Triglyceride Status TT CC 

IGFBP3 Diet & Nutrition / Triglyceride Status AA GA 

rs4889294 rs4889294 BCMO1 Diet & Nutrition / Vitamin A metabolism CC TT 

rs6564851 rs6564851 BCMO1 Diet & Nutrition / Vitamin A metabolism GG GG 

rs7501331 rs7501331 BCMO1 Diet & Nutrition / Vitamin A metabolism TT CC 

rs6420424 rs6420424 BCMO1 Diet & Nutrition / Vitamin A metabolism GG AA 

rs492602 rs492602 FUT2 Diet & Nutrition / Vitamin B 12 Status AA AA 

rs3741049 rs3741049 ACAT1 G22670A General Health / Blood Glucose AA GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs266729 

rs10885122 

Adiponectin is released in the 

bloodstream from fat cells, where it 

is involved in the control of fat 

metabolism and regulating glucose 

levels .CG was associated with type 

2 diabetes in the obese group only 

OR=2.45....P=0.02, and 59% risk of 

diabetes could be attributed to that. 

T=lower fasting glucoseG=higher 

fasting glucose 

ADIPOQ General Health / Blood Glucose GG CG 

ADRA2A General Health / Blood Glucose GG GG 

rs1405655 rs1405655 LXR General Health / Blood Glucose TT TT 

rs17373080 rs17373080 LXR General Health / Blood Glucose GG CC 

rs2695121 rs2695121 LXR General Health / Blood Glucose TT CC 

rs3135506 

The C (minor) allele is associated 

with: 

Higher risk of Cardiovascular 

disease. 

APOA5 General Health / Cardiovascular Health CC GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs662799 







metabolism. 


with: 



attack risk 


fat diets 


attack risk 


fat diets 

APOA5 General Health / Cardiovascular Health GG AA




METHOD: 




sequencing 


NOTES: 






beneficial 



rs1799945 rs1799945 HFE General Health / Cardiovascular Health GG CG 

rs3869109 rs3869109 HLA-C General Health / Cardiovascular Health GG AG 

rs5443 rs5443 HTR2A General Health / Cardiovascular Health TT CT 

rs8192678 rs8192678 PPARGC1A General Health / Cardiovascular Health TT CT 

rs4961 

The risk (T) allele responded better 

to diuretics and sodium-restricted 

diets, in that they tended to lower 

their blood pressure by ~10 mmHg 

points compared to rs4961(G;G) 

homozygotes similarly treated. 

ADD1 General Health / Clotting Factors TT GG 

rs1800775 

CETP encodes a protein that is 

involved in the transfer of 

cholesteryl ester from high density 

CETP General Health / Clotting Factors CC CC 

lipoprotein (HDL) to other 

lipoproteins. 

rs13146272 rs13146272 CYP4V2 General Health / Clotting Factors CC AA




METHOD: 




sequencing 


NOTES: 






beneficial 



rs3211719 

rs6025 

rs6048 

This gene encodes a protein called 

coagulation factor X that helps 

blood clot after an injury. Mutations 

can cause deficiency of the protein, 

which leads to excessive bleeding. 

he F5 gene encodes a protein that is 

called coagulation factor V. They 

that form blood clots to stop 

bleeding and trigger blood vessel 

repair after an injury. Mutations can 

cause abnormal bleeding. 


coagulation factor IX, which helps 

form blood clots. Mutations can 

cause blood clots to be unable to 

form and lead to excessive bleeding 

(hemophilia) or warfarin sensitivity, 

which can cause severe bleeding 

problems. 

F10 General Health / Clotting Factors GG AA 

F5 General Health / Clotting Factors TT CC 

F9 General Health / Clotting Factors GG GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs1613662 

The gene encodes a protein that is a 

receptor for collagen and plays an 

important role in collagen-induced 

platelet aggregation and thrombus 

formation. Mutations of this gene 

can cause a bleeding disorder. 

GP6 Pro219Ser General Health / Clotting Factors GG AA 

rs9898 rs9898 HRG Pro204Ser General Health / Clotting Factors TT CT 

rs5918 

C=increased resistance to blood 

thinning side effect of aspirin. 

ITGB3 General Health / Clotting Factors CC TT 

rs2227589 

Gene variants associated with deep 

vein thrombosis. 

SERPINC1 General Health / Clotting Factors TT CC




METHOD: 




sequencing 


NOTES: 






beneficial 



rs12273363 

rs6265 

Neurotrophins are chemicals that 

help to stimulate and control 

neurogenesis, BDNF being one of 

the most active. The C allele is 

associated with more with mood 

disorders than T.The minor C allele 

might increased activity in the 

amygdala (a region in brain). This 

might increase anxiety and 

emotional memory. 

Neurotrophins are chemicals that 

help to stimulate and control 

neurogenesis, BDNF being one of 

the most active. “T” allele carriers 

had lower blood BDNF than CC 

BDNF General Health / Cognitive CC TT 

BDNF General Health / Cognitive TT CT




METHOD: 




sequencing 


NOTES: 






beneficial 



rs3738401 

rs10174400 

This gene encodes a protein that 

helps neurons grow and assist 

cortical development through its 

interaction with other proteins. 

Mutations are associated with 

higher risk for schizophrenia. 

Contributes to the generation and 

propagation of action potentials 

throughout the brain.This gene 

increases the capacity for 

information processing between the 

dorsolateral prefrontal cortex and 

dorsal anterior cingulate cortex, 

which support higher cognitive 

functions. T (minor allele) 

=significantly higher general 

cognitive or “G” independent of 

gender and age. 

DISC1 General Health / Cognitive AA GA 

SCN2A General Health / Cognitive CC CC




METHOD: 




sequencing 


NOTES: 






beneficial 



rs4833095 

Toll Like Receptors get activated 

mainly by bacterial, viral and fungal 

products. Some of our junk protein 

can also activate TLRs. Once 

activated, they start a cascade that 

will produce cytokines and other 

inflammatory mediators to combat 

the infection. 

TLR1 General Health / Hayfever TT TT 

rs1049793 rs1049793 AOC1 / DAO General Health / Histamine Metabolism GG CG 

rs3918347 rs3918347 DAO General Health / Histamine Metabolism GG AG 

rs2073440 Histidine to Histamine HDC General Health / Histamine Metabolism GG TG 

rs901865 Histamine Receptor HRH1 General Health / Histamine Metabolism TT TC 

rs16940765 Histamine Receptor HRH4 General Health / Histamine Metabolism CC TT 

rs11662595 Histamine Receptor HRH4 General Health / Histamine Metabolism GG AA 

rs1799836 rs1799836 MAOB General Health / Histamine Metabolism TT TC 

rs1799929 rs1799929 NAT2 General Health / Histamine Metabolism TT TT 

rs1208 rs1208 NAT2 General Health / Histamine Metabolism GG GG 

rs1799930 rs1799930 NAT2 General Health / Histamine Metabolism AA GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs1801279 rs1801279 NAT2 General Health / Histamine Metabolism AA GG 

rs1041983 rs1041983 NAT2 General Health / Histamine Metabolism TT CC 

rs9275224 

The G allele of rs9275224 is 

reported to be associated with Iga 

HLA-DQA2 General Health / Kidney Health GG GG 

Glomerulonephritis 

rs2007044 rs2007044 CACNA1C General Health / Mental Health GG AG 

rs16944 rs16944 IL1B General Health / Mental Health GG AA 

rs20541 rs20541 IL13 General Health / Skin Health GG GG 

rs10484554 rs10484554 HLA-C 

General Health / Skin Health / Psoriasis 

TT 

CC 

rs10885122 

These receptors have a critical role 

in regulating neurotransmitter 

release from your fight or flight 

system (sympathetic nerves and 

adrenergic neurons) in the brain. 

When activated, these receptors 

induce low heart rate, low blood 

pressure and sedation 

ADRA2A General Health / Stress Response TT GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs1978340 rs1978340 GAD1 General Health / Stress Response AA GG 

rs3791878 rs3791878 GAD1 General Health / Stress Response GG GG 

rs3749034 rs3749034 GAD1 General Health / Stress Response GG GA 

rs6313 rs6313 HTR2A General Health / Stress Response AA GG 

rs6314 rs6314 HTR2A General Health / Stress Response AA GG 

rs5443 rs5443 HTR2A General Health / Stress Response TT CT 

rs6311 rs6311 HTR2A General Health / Stress Response TT CC 

rs2268494 rs2268494 OXTR General Health / Stress Response AA TT 

rs13316193 rs13316193 OXTR General Health / Stress Response TT TC 

rs1042778 rs1042778 OXTR General Health / Stress Response TT GT 

rs2268491 rs2268491 OXTR General Health / Stress Response TT CC 

rs53576 rs53576 OXTR (MAIN) General Health / Stress Response AA AA




METHOD: 




sequencing 


NOTES: 






beneficial 



rs1867277 

The FOXE1 protein regulates the 

transcription of thyroglobulin (Tg) 

and thyroid peroxidase (TPO).AA= 

production of FOXE1 gene is 

increased (by forming a complex 

with USF1/USF2 transcription 

factors).The higher level of 

production of FOXE1 gene 

associated with development of 

thyroid cancer. 

FOXE1 General Health / Thyroid Health AA AA 

rs8192678 rs8192678 PPARGC1A General Health Report / Blood Glucose TT CT 

rs1800961 rs1800961 HNF4A GENERAL INFLAMMATION TT CC 

rs3761847 rs3761847 TRAF1 General Inflammation / Bone Health GG AA 

rs7041 rs7041 GC General Inflammation / Tuberculosis AA CC 

rs602662 rs602662 FUT2 GI Health / Crohn'S Disease AA GG 

rs2187668 rs2187668 HLA-DQA1 GI Health / Celiac & Gluten Intolerance TT CC 

rs7775228 rs7775228 HLA-DQB1 GI Health / Celiac & Gluten Intolerance CC TT 

rs1800871 rs1800871 IL10 GI Health / Celiac & Gluten Intolerance AG GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs6822844 rs6822844 IL2, IL21 GI Health / Celiac & Gluten Intolerance TT GG 

rs3741049 rs3741049 ACAT1 G22670A GI Health / Dysbiosis AA GG 

rs2069840 rs2069840 IL6 GI Health / Gastrointestinal Immunology GG CC 

rs601338 rs601338 FUT2 GI Health / H Antigen AA GG 

rs602662 rs602662 FUT2 GI Health / H Antigen AA GG 

rs1047781 rs1047781 FUT2 GI Health / H Antigen TT AA 

rs492602 rs492602 FUT2 GI Health / H Antigen GG AA 

rs1878672 rs1878672 IL10 GI Health / H.Pylori CC CC 

rs10156191 rs10156191 AOC1 / DAO GI Health / Histamine Intolerance TT CT 

rs1049793 rs1049793 AOC1 / DAO GI Health / Histamine Intolerance GG CG 

rs3918347 rs3918347 DAO GI Health / Histamine Intolerance GG AG 

rs602662 rs602662 FUT2 GI Health / IBS AA GG 

rs5443 rs5443 HTR2A GI Health / IBS TT CT 

rs6311 rs6311 HTR2A GI Health / IBS TT CC 

rs1800871 rs1800871 IL10 GI Health / IBS AA GG 

rs10210302 rs10210302 ATG16L1 GI Health / IgA / Crohn's disease TT TT 

rs1061622 rs1061622 TNFRSF1B GI Health / Inflammation / IBS GG TG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs854571 rs854571 PON1 GI Health / Microbial defence / IBD TT TC 

rs662 rs662 PON1 Q192R GI Health / Microbial defence / IBD TT CC 

rs7946 rs7946 PEMT GI Health / Permeability TT TT 

rs4244593 rs4244593 PEMT GI Health /Permeability TT GG 

rs2289252 


coagulation factor XI that helps 

blood clot after an injury. Mutations 

F11,F11-AS1 Health Report / Clotting Factors TT CT 

can cause deficiency of the protein, 

which leads to excessive bleeding. 

rs6994992 rs6994992 NRG1 Health Report / Cognitive TT CT 

rs3746544 rs3746544 SNAP25 Health Report / Cognitive TT TT 

rs4343 rs4343 ACE G2328A Health Report / Kidney Health GG GA 

rs4343 rs4343 ACE G2328A Health Report / Stress Response GG GA 

rs429358 rs429358 APOE Immune Factors & Inflammation CC TT 

rs7412 rs7412 APOE Immune Factors & Inflammation CC CC 

rs10210302 rs10210302 ATG16L1 Immune Factors & Inflammation TT TT 

rs7216389 rs7216389 GSDMB Immune Factors & Inflammation TT CT




METHOD: 




sequencing 


NOTES: 






beneficial 



rs6822844 rs6822844 IL2, IL21 Immune Factors & Inflammation TT GG 

rs2280714 

IFN-regulatory factor 5 gene 

increases IFN-alpha. Interferon 

alpha induces the kynurenine 

pathway and is associated with 

depression because of NMDA 

overactivity.The C (minor) allele is 

associated with:Possible increased 

risk of depression when paired with 

STAT4 T allele. Increased levels of 

IFN-alpha protein. 

IRF5 Immune Factors & Inflammation CC CT 

rs1405655 rs1405655 LXR Immune Factors & Inflammation TT TT 

rs17373080 rs17373080 LXR Immune Factors & Inflammation GG CC 

rs2695121 rs2695121 LXR Immune Factors & Inflammation TT CC




METHOD: 




sequencing 


NOTES: 






beneficial 



rs4833095 

Toll Like Receptors get activated 

mainly by bacterial, viral and fungal 

products. Some of our junk protein 

can also activate TLRs. Once 

activated, they start a cascade that 

will produce cytokines and other 

inflammatory mediators to combat 

the infection. 

TLR1 Immune Factors & Inflammation TT TT 

rs3775291 rs3775291 TLR3 Immune Factors & Inflammation CC CC 

rs1061622 rs1061622 TNFRSF1B Immune Factors & Inflammation GG TG 

rs3761847 rs3761847 TRAF1 Immune Factors & Inflammation GG AA 

rs7775228 rs7775228 HLA-DQB1 

Immune Factors & Inflammation / 

Allergies 

CC 

TT 

rs231779 rs231779 CTLA4 


Autoimmunity 

TT 

TT 

rs231775 rs231775 CTLA4 


Autoimmunity 

GG 

GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs3087243 rs3087243 CTLA4 

rs11575839 rs11575839 HLA-C 

rs10484554 rs10484554 HLA-C 

rs2187668 rs2187668 HLA-DQA1 

rs9275224 

rs3135391 

rs3135388 

Helps to recognise foreign particles 

when they enter our body and fight 

them away in an immune response. 

Increases risk for 

autoimmunity/inflammation to 

toxins or infections. Each A 

allele=very significant increase in 

autoimmune disease risk. 

rs3135388 

HLA-DQA2 

HLA-DRB1 

HLA-DRB5/HLA-DRB1/HLA-DRA/HLA- 

DQB1/ HLA-DQA1 


Autoimmunity 


Autoimmunity 


Autoimmunity 


Autoimmunity 


Autoimmunity 


Autoimmunity 


Autoimmunity 

A,G 

AA 

TT 

AA 

AA 

AA 

AA 

GG 

GG 

CC 

CC 

GG 

GG 

GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs11889341 rs11889341 STAT4 

rs10181656 rs10181656 STAT4 

rs897200 rs897200 STAT4 

rs1517352 rs1517352 STAT4 

rs6677604 

rs1990760 

C3, a protein coding gene, is part of 

a system of proteins that fight 

against disease. 

This gene encodes a protein that is 

involved with RNA translation 

initiation, splicing, and assembly. It 

is also involved in the formation of 

embryos and sperm and cellular 

growth and division. 


Autoimmunity 


Autoimmunity 


Autoimmunity 


Autoimmunity 

CFH Immune Factors & Inflammation / IgA AA GG 

IFIH1 Immune Factors & Inflammation / IgA TT CC 

TT 

GG 

AA 

CC 

TT 

GG 

CC 

AA




METHOD: 




sequencing 


NOTES: 






beneficial 



rs2229765 

IGF1R encodes for insulin growth 

factor receptors; overexpression 

can stop cell death by enhancing 

cell survival and is present in 

malignant tissues. AA= lower levels 

of IGF-1 protein.Increased longevity 

in males 15% of people have AA. 

Most people have AG. 

IGF1R Immune Factors & Inflammation / IgA AA GG 

rs9357155 rs9357155 PSMB8 Immune Factors & Inflammation / IgA AA GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs2814778 

rs2814778 is within the DARC gene, 

which encodes the Duffy blood 

group antigen [PMID 7663520]. This 

SNP shows an almost perfectly fixed 

difference in frequency between 

Europeans and those with African 

ancestry. (One exception appears to 

be a certain population of Czech 

gypsies, and certain non-Ashkenazi 

Jewish populations.) Additionally 

the Namibian San samples of the 

CEPH-HGDP are, uncharacteristically 

for Africans, all AA homozygotes for 

this SNP.The rs2814778 (G) allele is 

associated with African populations, 

while rs2814778 (A) is associated 

with European populations and 

southwestern Native American 

populations. 

ACKR1 Immune Factors & Inflammation / IgE CC TT




METHOD: 




sequencing 


NOTES: 






beneficial 



rs2251746 


initiates the body's allergic 

response. High levels of serum IgE 

are associated with allergies, and 

are mediators of autoimmune 

diseases. 

FCER1A Immune Factors & Inflammation / IgE CC TT 

rs2858331 rs2858331 HLA-DQB1 Immune Factors & Inflammation / IgE GG AG 

rs2240032 rs2240032 RAD50 Immune Factors & Inflammation / IgE TT CC 

rs2040704 rs2040704 RAD50 Immune Factors & Inflammation / IgE GG AA 

rs1801274 


plays an important role in the 

immune system response by 

fighting off pathogens. It is 

FCGR2A Immune Factors & Inflammation / IgG GG GG 

associated with higher susceptibility 

to arthritis, lupus, and malaria. 

rs10757278 rs10757278 DMRTA1 


Microbial defence 

GG 

GG 

rs854571 rs854571 PON1 



TT 

TC




METHOD: 




sequencing 


NOTES: 






beneficial 



rs662 rs662 PON1 Q192R 

rs1816702 rs1816702 TLR2 

rs4986791 rs4986791 TLR4 

rs4986790 rs4986790 TLR4 

rs6853 rs6853 MYD88 

rs4986790 rs4986790 TLR4 










Vaccine Response 


Vaccine Response 

rs1800871 rs1800871 IL10 Immune Factors and Inflammation AA GG 

rs1878672 rs1878672 IL10 Immune Factors and Inflammation CC CC 

rs3024490 rs3024490 IL10 Immune Factors and Inflammation AA CC 

rs20541 rs20541 IL13 Immune Factors and Inflammation AA GG 

rs1143643 rs1143643 IL1B Immune Factors and Inflammation CC CC 

rs16944 rs16944 IL1B Immune Factors and Inflammation GG AA 

TT 

TT 

TT 

GG 

GG 

GG 

CC 

CC 

CC 

AA 

AA 

AA




METHOD: 




sequencing 


NOTES: 






beneficial 



rs1801275 rs1801275 IL4R Immune Factors and Inflammation GG AG 

rs2069812 Anti-inflamatory cytokines. IL5 Immune Factors and Inflammation GG AG 

rs2069840 rs2069840 IL6 Immune Factors and Inflammation GG CC 

rs7529229 rs7529229 IL6R Immune Factors and Inflammation CC TC 

rs6994992 rs6994992 NRG1 Immune Factors and Inflammation TT CT 

rs10757278 rs10757278 STAT1 Immune Factors and Inflammation GG GG 

rs6503691 rs6503691 STAT3 Immune Factors and Inflammation CC CC 

rs744166 rs744166 STAT3 Immune Factors and Inflammation AA AA 

rs8069645 rs8069645 STAT3 Immune Factors and Inflammation GG AA 

rs361525 Tumor Necrosis Factor TNF -238 Immune Factors and Inflammation AA GG 

rs1800629 Tumor Necrosis Factor TNF -308 Immune Factors and Inflammation AA GG 

rs2282679 rs2282679 GC 

Immune Modulation / Vitamin D & 

GcMAF 

GG 

TT 

rs7041 rs7041 GC 


GcMAF 

CC 

CC 

rs1851024 rs1851024 GC 


GcMAF 

GG 

AA




METHOD: 




sequencing 


NOTES: 






beneficial 



rs703842 rs703842 CYP27B1 

rs10500804 rs10500804 CYP2R1 

rs12794714 rs12794714 CYP2R1 

rs2060793 rs2060793 CYP2R1 

rs61495246 rs61495246 CYP2R1 

rs1544410 rs1544410 VDR Bsm1 

rs731236 rs731236 VDR Taql 

Immune Modulation / Vitamin D 

Metabolism 


Metabolism 


Metabolism 


Metabolism 


Metabolism 


Metabolism 


Metabolism 

rs3733890 rs3733890 BHMT Methylation AA GG 

rs567754 rs567754 BHMT-02 Methylation TT TT 

rs2851391 Homocysteine to Cystathionine. CBS Methylation TT TC 

rs4920037 Homocysteine to Cystathionine. CBS Methylation AA GA 

AA 

GG 

AA 

AA 

GG 

TT 

GG 

AA 

TG 

GA 

AG 

AA 

TT 

GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs234706 Homocysteine to Cystathionine CBS C699T Methylation AA GA 

rs1677693 FOLR2 to DHF, DHF to THF DHFR Methylation TT GT 

rs705415 rs705415 DMGDH Methylation TT CT 

rs2071010 

Binds folates to transport the inside 

cells. 

FOLR1 Methylation AA GG 

rs651933 

Binds folates to transport the inside 

cells. 

FOLR2 Methylation GG AA 

rs17851582 

Arginine to Guanidoacetate to 

Creatine (SAMe) 

GAMT Methylation AA GG 

rs55776826 

Arginine to Guanidoacetate to 

Creatine (SAMe) 

GAMT Methylation TT CC 

rs3780127 rs3780127 GGH Methylation AA GG 

rs3780126 GGH Methylation TT GA 

rs72558181 rs72558181 MAT1A Methylation TT CC 

rs2236225 

THF to Purines (ATP & GTP) & 10- 

Formyl-THF to 5,10 Methenyl THF to 

MTHFD1 Methylation AA GA 

5,10 Methylene THF 

rs1801131 rs1801131 MTHFR A1298C Methylation GG TT




METHOD: 




sequencing 


NOTES: 






beneficial 



rs1801133 rs1801133 MTHFR C677T Methylation AA GG 

rs2733103 

Helps regulate carbon flow through 

the folate-dependent onecarbonmetabolic 

network that 

supplies carbon for the biosynthesis 

of purines,thymidine, and amino 

acids. 

MTHFS Methylation TT CC 

rs2275565 rs2275565 MTR Methylation TT GG 

rs3820571 rs3820571 MTR Methylation GG GG 

rs2275568 rs2275568 MTR Methylation TT CC 

rs10925257 rs10925257 MTR Methylation GG AA 



rs1532268 rs1532268 MTRR Methylation TT CC 

rs1802059 rs1802059 MTRR -11 A664A Methylation AA GG 

rs1801394 rs1801394 MTRR A66G Methylation GG GG 

rs162036 rs162036 MTRR K350A Methylation GG AG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs7946 rs7946 PEMT Methylation TT TT 

rs4244593 rs4244593 PEMT Methylation TT GG 

rs1051266 rs1051266 SLC19A1 Methylation CC CC 

rs2274894 

iNOS, a reactive free radical 

generator. 

NOS2 Mitochondrial Function TT TT 

rs2248814 

iNOS, a reactive free radical 

generator 

NOS2 Mitochondrial Function AA AA 

rs1800779 eNOS production. NOS3 Mitochondrial Function GG AA 

rs8192678 rs8192678 PPARGC1A Mitochondrial Function TT CT 

rs2970869 rs2970869 PPARGC1A Mitochondrial Function TT CC 

rs3774923 rs3774923 PPARGC1A Mitochondrial Function TT CC 

rs4880 rs4880 SOD2 Mitochondrial Function GG GG 

rs659366 

UCP are mitochondrial transporter 

proteins that create proton leaks 

across the inner mitochondrial 

membrane. 

UCP2 Mitochondrial Function CC CT 

rs7134594 

Conversion of vitamin B-12 into 

adenosylcobalamin 

MMAB 

Mitochondrial Function / Cobalamin 

Contribution 

CC 

CC




METHOD: 




sequencing 


NOTES: 






beneficial 



rs4147730 

rs1142530 

rs2075626 

Electron Transport Chain, ATP 

Production 


Production 


Production 

NDUFS3 Mitochondrial Function / Complex I AA GA 

NDUFS7 Mitochondrial Function / Complex I TT TT 

NDUFS8 Mitochondrial Function / Complex I CC TT 

rs3741049 rs3741049 ACAT1 G22670A Mitochondrial Function / Krebs Cycle AA GG 

rs2302729 rs2302729 CACNA1C Neurotransmitters TT CC 

rs2007044 rs2007044 CACNA1C Neurotransmitters GG AG 

rs216013 rs216013 CACNA1C Neurotransmitters GG AA 

rs1006737 rs1006737 CACNA1C / SLC36A3 Neurotransmitters AA GG 

rs72547566 Adrenaline metabolism (NAD,B1) ALDH3A2 

Neurotransmitters / Adrenaline 

Metabolism 

TT 

CC 

rs10994336 rs10994336 ANK3 Neurotransmitters / Biopterin Cycle TT CC 



rs1677693 Biopterin Recycling DHFR Neurotransmitters / Biopterin Cycle TT GT




METHOD: 




sequencing 


NOTES: 






beneficial 



rs3783642 rs3783642 GCH1 Neurotransmitters / Biopterin Cycle CC TC 

rs3783641 rs3783641 GCH1 Neurotransmitters / Biopterin Cycle AA TA 

rs3783637 rs3783637 GCH1 Neurotransmitters / Biopterin Cycle TT CC 

rs8007267 rs8007267 GCH1 C36378991T Neurotransmitters / Biopterin Cycle TT CT 

rs10483639 rs10483639 GCH1 G55306457C Neurotransmitters / Biopterin Cycle CC GC 

rs1800779 Biopterin Recycling. NOS3 Neurotransmitters / Biopterin Cycle GG AA 

rs5030858 rs5030858 PAH Neurotransmitters / Biopterin Cycle AA GG 

rs5030849 rs5030849 PAH Neurotransmitters / Biopterin Cycle TT CC 

rs6356 Tyrosine to L-Dopa TH Neurotransmitters / Biopterin Cycle TT CC 

rs2070762 Tyrosine to L-Dopa TH Neurotransmitters / Biopterin Cycle GG AG 

rs4633 rs4633 COMT H62H 

Neurotransmitters / Dopamine & 

Adrenaline Metabolism 

CC 

CC 

rs4680 rs4680 COMT V158M 



AA 

GG 

rs737866 rs737866 COMT/TXNRD2 A4251G 



TT 

TC




METHOD: 




sequencing 


NOTES: 






beneficial 



rs2020917 rs2020917 COMT/TXNRD2 C4622T 

rs1611115 rs1611115 DBH 

rs1108580 rs1108580 DBH 

rs1018381 

Synaptic vesicle trafficking, 

neurotransmitter release.Role in 

regulation of cell surface exposure 

of Dopamine Receptor 2 

DTNBP1 



Neurotransmitters / Dopamine 

Metabolism 


Metabolism 


Metabolism 

rs686 rs686 DRD1 Neurotransmitters / Dopamine Receptor AA GA 

rs4532 rs4532 DRD1 Neurotransmitters / Dopamine Receptor CC CT 

rs265981 rs265981 DRD1 Neurotransmitters / Dopamine Receptor AA AG 

rs1079727 rs1079727 DRD2 Neurotransmitters / Dopamine Receptor CC TT 



rs1801028 rs1801028 DRD2 Neurotransmitters / Dopamine Receptor CG GG 

rs4648317 rs4648317 DRD2 Neurotransmitters / Dopamine Receptor AA GG 

CC 

TT 

GG 

AA 

CT 

CC 

AG 

GG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs4648319 rs4648319 DRD2 Neurotransmitters / Dopamine Receptor AA GG 

rs6279 rs6279 DRD2 Neurotransmitters / Dopamine Receptor GG GC 

rs1076560 rs1076560 DRD2 Neurotransmitters / Dopamine Receptor AA CC 

rs1079596 rs1079596 DRD2 Neurotransmitters / Dopamine Receptor TT CC 

rs1079597 rs1079597 DRD2 Neurotransmitters / Dopamine Receptor TT CC 

rs2283265 rs2283265 DRD2 Neurotransmitters / Dopamine Receptor AA CC 

rs1800498 rs1800498 DRD2 Neurotransmitters / Dopamine Receptor AA AA 

rs1800497 rs1800497 DRD2 (MAIN) Neurotransmitters / Dopamine Receptor AA GG 

rs6277 rs6277 DRD2 (MAIN) Neurotransmitters / Dopamine Receptor AA GA 

rs1799978 rs1799978 DRD2 A4651G Neurotransmitters / Dopamine Receptor CC TT 

rs2242592 rs2242592 DRD2 C71572T Neurotransmitters / Dopamine Receptor AA GA 

rs2242592 rs2242592 DRD2 C71572T Neurotransmitters / Dopamine Receptor GG GA 

rs12364283 rs12364283 DRD2 T4047C Neurotransmitters / Dopamine Receptor GG AA 


rs167771 rs167771 DRD3 Neurotransmitters / Dopamine Receptor GG AA 

rs1049793 rs1049793 AOC1 / DAO Neurotransmitters / Dopamine Synthesis GG CG 

rs3918347 rs3918347 DAO Neurotransmitters / Dopamine Synthesis GG AG




METHOD: 




sequencing 


NOTES: 






beneficial 



rs3741775 rs3741775 DAO Neurotransmitters / Dopamine Synthesis CC AC 

rs6323 rs6323 MAO A R297R 

rs1137070 rs1137070 MAOA 

rs1799836 rs1799836 MAOB 

rs3219151 

GABA receptor. TT=higher cortisol, 

CT=Intermediate. 

Neurotransmitters / Dopamine, 

Serotonin, Adrenaline, Noradrenaline 

Metabolism 



Metabolism 



Metabolism 

GABRA6 Neurotransmitters / Glutamate ➜ GABA TT CT 

rs3791878 rs3791878 GAD1 Neurotransmitters / Glutamate ➜ GABA GG GG 

rs3749034 rs3749034 GAD1 Neurotransmitters / Glutamate ➜ GABA GG GA 

rs2241165 rs2241165 GAD1 Neurotransmitters / Glutamate ➜ GABA CC CT 

rs4668338 rs4668338 GAD1 Neurotransmitters / Glutamate ➜ GABA GG CC 

rs6994992 rs6994992 NRG1 Neurotransmitters / Glutamate ➜ GABA TT CT 

GG 

TT 

TT 

TT 

CC 

TC



contact us 


METHOD: 




sequencing 


NOTES: 






beneficial 



rs671 rs671 ALDH2 

rs2238151 rs2238151 ALDH2 

rs40147 

rs3785143 

rs3785152 

rs2242446 

Noradrenaline Transporter, 

reuptake of noradrenaline 







SLC6A2 

SLC6A2 

SLC6A2 

SLC6A2 C5884T 

rs2167364 rs2167364 DDC 

rs6592961 rs6592961 DDC 

rs2329340 rs2329340 DDC 

Neurotransmitters / Noradrenaline 

Metabolism 


Metabolism 


Metabolism 


Metabolism 


Metabolism 


Metabolism 

Neurotransmitters / Serotonin & 

Dopamine Synthesis 





AA 

TT 

AA 

TT 

TT 

CC 

CC 

AA 

TT 

GG 

CC 

GA 

CC 

CC 

TT 

TT 

GG 

CT



contact us 


METHOD: 




sequencing 


NOTES: 






beneficial 



rs1451375 rs1451375 DDC 



rs11077820 Serotonin to Melatonin AANAT 

Neurotransmitters / Serotonin ➜ 

Melatonin 

CC 

TT 

rs7997012 rs7997012 HTR2A Neurotransmitters / Serotonin Receptors AA AG 

rs4565946 rs4565946 TPH2 Neurotransmitters I Biopterin I Serotonin GG TT 

rs4570625 rs4570625 TPH2 Neurotransmitters I Biopterin I Serotonin GG GG 

rs2851391 

It is responsible for using vitamin B6 

to convert amino acids called 

homocysteine and serine to a 

molecule called cytathionine. 

Another enzyme converts 

cystathionine to cysteine, which is 

used to build proteins or is broken 

down and excreted in urine. 

CBS Trans-sulfuration TT TC 

AA 

CA



contact us 


METHOD: 




sequencing 


NOTES: 






beneficial 



rs4920037 

rs234706 

It is responsible for using vitamin B6 

to convert amino acids called 

homocysteine and serine to a 

molecule called cytathionine. 

Another enzyme converts 

cystathionine to cysteine, which is 

used to build proteins or is broken 

down and excreted in urine. 

AA=Increased responsiveness to 

homocysteine-lowering effects of 

folic acid. Limits homocysteine into 

downstream path. People with CBS 

mutations will need to be careful 

with sulphur containing 

supplements. Increased risk for 

ammonia detoxification issues. 

CBS Trans-sulfuration AA GA 

CBS C699T Trans-sulfuration AA GA 

rs2273684 rs2273684 GSS Trans-sulfuration TT GG 

rs6088659 rs6088659 GSS A5997G Trans-sulfuration TT CC

Gene Variant Report issued

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