Gene Variant Report issued
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Lifestyle Genomics Research Centre Ltd.<br />
Plymouth Science Park, 1 Davy Road, Derriford, Plymouth, PL6 8BX , UNITED KINGDOM contact us<br />
SAMPLE PROCESSED BY:<br />
METHOD:<br />
DATA CHECKED FOR ACCURACY BY:<br />
Genome Centre at BARTS and The London School of Medicine and Dentistry<br />
Fluidigm TaqMan probe-based SNP genotyping / Illumina MiSeq, Next <strong>Gene</strong>ration<br />
sequencing<br />
Genome Centre at BARTS and The London School of Medicine and Dentistry<br />
NOTES:<br />
genotype has no risk alleles<br />
genotype has one risk allele<br />
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genotype has two risk allels<br />
either allele can be a risk or be<br />
beneficial<br />
Ctr+F to activate Search Engine: Look up genes, rsids, pathways / traits<br />
SNP RSID INTERPRET ☞ PARENT GENE & VARIANT ⚛ CATEGORY ☤ / PATHWAY ⥹ RISK ALLELES !! cp00035774<br />
rs6822844 rs6822844 IL2, IL21 Immune Factors & Inflammation TT GG<br />
rs2280714<br />
IFN-regulatory factor 5 gene<br />
increases IFN-alpha. Interferon<br />
alpha induces the kynurenine<br />
pathway and is associated with<br />
depression because of NMDA<br />
overactivity.The C (minor) allele is<br />
associated with:Possible increased<br />
risk of depression when paired with<br />
STAT4 T allele. Increased levels of<br />
IFN-alpha protein.<br />
IRF5 Immune Factors & Inflammation CC CT<br />
rs1405655 rs1405655 LXR Immune Factors & Inflammation TT TT<br />
rs17373080 rs17373080 LXR Immune Factors & Inflammation GG CC<br />
rs2695121 rs2695121 LXR Immune Factors & Inflammation TT CC
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