Gene Variant Report issued
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Lifestyle Genomics Research Centre Ltd.<br />
Plymouth Science Park, 1 Davy Road, Derriford, Plymouth, PL6 8BX , UNITED KINGDOM contact us<br />
SAMPLE PROCESSED BY:<br />
METHOD:<br />
DATA CHECKED FOR ACCURACY BY:<br />
Genome Centre at BARTS and The London School of Medicine and Dentistry<br />
Fluidigm TaqMan probe-based SNP genotyping / Illumina MiSeq, Next <strong>Gene</strong>ration<br />
sequencing<br />
Genome Centre at BARTS and The London School of Medicine and Dentistry<br />
NOTES:<br />
genotype has no risk alleles<br />
genotype has one risk allele<br />
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genotype has two risk allels<br />
either allele can be a risk or be<br />
beneficial<br />
Ctr+F to activate Search Engine: Look up genes, rsids, pathways / traits<br />
SNP RSID INTERPRET ☞ PARENT GENE & VARIANT ⚛ CATEGORY ☤ / PATHWAY ⥹ RISK ALLELES !! cp00035774<br />
rs662799<br />
The G (minor) presumably reduces<br />
levels of APOA5 protein.<br />
Associations of APOA5 transcripts<br />
with PPARA and CPT1A1 transcripts<br />
suggest that APOA5 expression is<br />
intimately linked to hepatic lipid<br />
metabolism.<br />
The G (minor) allele is associated<br />
with:<br />
Each G=higher tryglycerides<br />
AG causes 1.4x higher early heart<br />
attack risk<br />
AG causes less weight gain on high<br />
fat diets<br />
GG causes 2x higher early heart<br />
attack risk<br />
GG causes less weight gain on high<br />
fat diets<br />
APOA5 Diet & Nutrition / Triglyceride Status GG AA
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