18.02.2019 Views

Gene Variant Report issued

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Lifestyle Genomics Research Centre Ltd.<br />

Plymouth Science Park, 1 Davy Road, Derriford, Plymouth, PL6 8BX , UNITED KINGDOM<br />

contact us<br />

SAMPLE PROCESSED BY:<br />

METHOD:<br />

DATA CHECKED FOR ACCURACY BY:<br />

Genome Centre at BARTS and The London School of Medicine and Dentistry<br />

Fluidigm TaqMan probe-based SNP genotyping / Illumina MiSeq, Next <strong>Gene</strong>ration<br />

sequencing<br />

Genome Centre at BARTS and The London School of Medicine and Dentistry<br />

NOTES:<br />

genotype has no risk alleles<br />

genotype has one risk allele<br />

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genotype has two risk allels<br />

either allele can be a risk or be<br />

beneficial<br />

Ctr+F to activate Search Engine: Look up genes, rsids, pathways / traits<br />

SNP RSID INTERPRET ☞ PARENT GENE & VARIANT ⚛ CATEGORY ☤ / PATHWAY ⥹ RISK ALLELES !! cp00035774<br />

rs894160<br />

rs1799986<br />

CC (major) =does worse with a high<br />

complex carb diet with regard to<br />

weight.People with the "T" or minor<br />

allele do better with complex carbs<br />

and worse with saturated fat. The T<br />

allele helps protects from weight<br />

gain from a higher complex carb<br />

diet, but causes weight gain on a<br />

lower carb complex carb diet and<br />

insulin resistance on a higher<br />

saturated fat diet.<br />

The C (major) does better with<br />

saturated fat (decreased weight<br />

gain)The AG genotype is associated<br />

with normal saturated fat levels.<br />

PLIN1<br />

Diet & Nutrition / Response to<br />

Carbohydrates<br />

LRP1 Diet & Nutrition / Saturated Fat TT CC<br />

rs744166 rs744166 STAT3 Diet & Nutrition / Saturated Fat GG AA<br />

rs8069645 rs8069645 STAT3 Diet & Nutrition / Saturated Fat GG AA<br />

rs651821<br />

TT = Decreased triglyceride levels.<br />

CC = Higher triglycerides.<br />

APOA5 Diet & Nutrition / Triglyceride Status CC TT<br />

CC<br />

CC

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