18.02.2019 Views

Gene Variant Report issued

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Lifestyle Genomics Research Centre Ltd.<br />

Plymouth Science Park, 1 Davy Road, Derriford, Plymouth, PL6 8BX , UNITED KINGDOM contact us<br />

SAMPLE PROCESSED BY:<br />

METHOD:<br />

DATA CHECKED FOR ACCURACY BY:<br />

Genome Centre at BARTS and The London School of Medicine and Dentistry<br />

Fluidigm TaqMan probe-based SNP genotyping / Illumina MiSeq, Next <strong>Gene</strong>ration<br />

sequencing<br />

Genome Centre at BARTS and The London School of Medicine and Dentistry<br />

NOTES:<br />

genotype has no risk alleles<br />

genotype has one risk allele<br />

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genotype has two risk allels<br />

either allele can be a risk or be<br />

beneficial<br />

Ctr+F to activate Search Engine: Look up genes, rsids, pathways / traits<br />

SNP RSID INTERPRET ☞ PARENT GENE & VARIANT ⚛ CATEGORY ☤ / PATHWAY ⥹ RISK ALLELES !! cp00035774<br />

rs3738401<br />

rs10174400<br />

This gene encodes a protein that<br />

helps neurons grow and assist<br />

cortical development through its<br />

interaction with other proteins.<br />

Mutations are associated with<br />

higher risk for schizophrenia.<br />

Contributes to the generation and<br />

propagation of action potentials<br />

throughout the brain.This gene<br />

increases the capacity for<br />

information processing between the<br />

dorsolateral prefrontal cortex and<br />

dorsal anterior cingulate cortex,<br />

which support higher cognitive<br />

functions. T (minor allele)<br />

=significantly higher general<br />

cognitive or “G” independent of<br />

gender and age.<br />

DISC1 <strong>Gene</strong>ral Health / Cognitive AA GA<br />

SCN2A <strong>Gene</strong>ral Health / Cognitive CC CC

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