Annual-Report-2019

HOST LABORATORIES IN
LIFE & HEALTH SCIENCES
CENTRE D’ÉTUDE DES PATHOLOGIES RESPIRATOIRES (CEPR)
UMR 1100 - INSERM, UNIVERSITÉ DE TOURS
Respiratory diseases have a major impact in medical and socio-economic terms. It is against this
backdrop that the CEPR is aimed to develop innovative research that gives a better understanding
of the pathophysiology of these diseases and improves inhalation therapy devices. These activities
therefore fall in line with Inserm’s scientific priorities which are: - To identify the mechanisms at work in respiratory
mucosal cell alterations and characterise their regulation during inflammatory and infectious processes; - To identify the
cellular and molecular mechanisms that regulate tissue remodelling in the various structures of the respiratory system;
- To develop better targeted treatment strategies. This translational research has yielded an abundance of results that are
complementary. Also, knowledge transfer from CEPR’s scientific programmes was achieved both at the academic level
(e.g. publications, oral presentations, student training, conferences organisation, etc), at the socio-economic level (e.g.
acquisition of licences, patents deposits, development of public-private partnerships, etc) and at the clinical level (e.g.
coordination of three national “PHRC” programs by clinicians affiliated with the CEPR’s three teams, etc).
GROUPE DE RECHERCHES SUR L’ENERGÉTIQUE DES MILIEUX
IONISÉS (GREMI) - UMR 7344 - UNIVERSITE D’ORLEANS, CNRS
The host laboratory is the GREMI (Groupe de Recherches sur l’Energétique des
Milieux Ionisés), mainly located on the university campus in Orléans and with a
branch in Bourges 120 km south or Orléans. Created in 1982, the GREMI is a joint University of Orléans /
CNRS research unit focusing on plasma and laser processes and their applications in a wide range of fields:
energetics, materials, micro-electronics, nanotechnologies, metrology, radiation sources, biomedicine,
transport, and the environment. About 30 permanent position professors and researchers develop their
research with the help of 10 engineers, technicians and administrative staff. The laboratory also welcomes
around 20 PhD students and post-docs. The GREMI is one of the major plasma processing laboratories in
France and its expertise is internationally recognized in many areas involving plasma properties. Its facilities
comprise a substantial experimental infrastructure dedicated both to the production of plasma media and to
state-of-the-art plasma diagnostics. Modeling, strongly linked to experimentation, is also an important aspect
of the performed research.
Life & Health Sciences 2019
IMAGERIE MULTIMODALE MULTIÉCHELLE ET MODÉLISATION
DU TISSU OSSEUX ET ARTICULAIRE (I3MTO) - EA 4708 -
UNIVERSITÉ D’ORLÉANS
The I3MTO laboratory is recognised for the development of new microarchitectural indicators
risk factors of osteoporosis and osteoarthritis in vivo on radiographs. Our first aim is to
predict early bone erosion in link with rheumatoid arthritis at the metacarpal joints. Herein,
we focus on the characterisation of macro-architecture, microarchitecture and bone strength in both human
and animal models. We have a particular interest in studying the changes of bone quality induced by the
osteoporosis, ageing, menopause, physical activity, nutrition, and medications. Our second area of research
aims to elucidate the causes of the initiation and progression of osteoarthritis and other degenerative joint
diseases and to create and improve treatment and prevention strategies.
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