Life & Health Sciences 201944AROUND THE PROJECT OFDr FRÉDÉRIC JEAN-ALPHONSEPublication review. Biased Signaling and Allosteric Modulationat the FSHR., Landomiel F, De Pascali F,Raynaud P, Jean-Alphonse F, Yvinec R,Pellissier LP, Bozon V, Bruneau G, Crépieux P,Poupon A, Reiter E. Frontiers Endocrinology2019, Mar 13;10:148AROUND THE PROJECT OFProf. MANUELA SIMONIScientific publications. Riccetti L, Sperduti S, Lazzaretti C, Klett D,De Pascali F, Paradiso E, Limoncella S, PotìF, Tagliavini S, Trenti T, Galano E, PalmeseA, Satwekar A, Daolio J, Nicoli A, Villani MT,Aguzzoli L, Reiter E, Simoni M, CasariniL (2019) Glycosylation Pattern and in vitroBioactivity of Reference Follitropin alfa andBiosimilars. Front. Endocrinol., 24 July 2019https://doi.org/10.3389/fendo.2019.00503. Simoni M, Huhtaniemi I, Santi D, CasariniL (2019) Research Topic Follicle-stimulatinghormone: fertility and beyond. Editorial. FrontEndocrinol, 06 September 2019 https://doi.org/10.3389/fendo.2019.00610. Simoni M, Santi D (2019) Opinion - FSHTreatment Of Male Idiopathic Infertility: TimeFor A Paradigm Change. Andrology. 2019 Dec24. doi: 10.1111/andr.12746. [Epub ahead ofprint]. Santi D, De Vincentis S, Alfano P, BalerciaG, Calogero AE, Cargnelutti F, Coccia ME,Condorelli RA, Dal Lago A, De Angelis C,Gallo M, Iannantuoni N, Lombardo F, MarinoA, Mazzella M, Pallotti F, Paoli D, PivonelloR, Rago R, Rampini M, Salvio G, SimoniM. Use of follicle-stimulating hormone(FSH) for the male partner of idiopathicinfertile couples in Italy: Results from amulticentre, observational, clinical practicesurvey. Andrology. 2019 Dec 24. doi: 10.1111/andr.12748.. Sperduti S, Limoncella S, Lazzaretti C,Paradiso E, Riccetti L, Turchi S, Ferrigno I,Bertacchini J, Palumbo C, Potì F, LongobardiS, Millar RP, Simoni M, Newton CL, Casarini L(2019) GnRH antagonists produce differentialmodulation of the signaling pathwaysmediated by GnRH receptors. Int J Mol Sci.2019 Nov 7;20(22). Pii: E5548. Doi: 10.3390/ijms20225548.TARGETING GPCR TO GENERATE LIFE,PRESERVE THE ENVIRONMENT AND IMPROVEANIMAL BREEDING: TECHNOLOGICAL ANDPHARMACOLOGICAL CHALLENGESLE STUDIUM CONFERENCESCo-organised by Prof. ManuelaSimoni and Dr Frédéric Jean-Alphonse and their host scientists,the conference gathering Europeanspecialists of GPCRs involvedin the biology of reproductionof both Human and Animals,enabling to build and/or strengthencollaborations, to analyse thecurrent challenges around thistheme and to envision novelpathways not only to optimisereproduction but also to reduce theenvironmental and societal burdenof the current technologies.The panel of invited scientistscovered a broad range ofspecialties, from basic molecular biology to cellular and physiologicalbiology as well as human biology with contributionsvfrom the area of lifesciences (biology, pharmacology, chemistry, human and veterinary medicine),humanities (bioethics) and industry (a big gonadotropin producing company).The Conference served as a springboard for a Consortium, which convenedagain in a Workshop in December 18-19, 2019 in Tours and is currentlywriting an application to the H2020 FET-Open RIA project.LES PERTURBATEURS ENDOCRINIENS ET LANOUVELLE TOXICOLOGIELE STUDIUM LECTURESEnvironmental pollutants have many presumed health effects: respiratory,metabolic, cardiovascular, neurodegenerative, neurodevelopmental, fertility,allergies, etc.Their effects needs to be integratedinto the broader study of theexposome, which corresponds toall exposures (physical, chemical,biological, psychosocial) throughoutlife. Research has focused on acategory of toxic substances that actby modifying the effects or quantitiesof hormones: endocrine disruptors(EDs). These toxic compounds canmimic or alter very fine physiologicalregulations with harmfulconsequences for the organism. Theunusual behaviour of EPs leads to aquestioning of traditional dogmas oftoxicology, in particular concerningthe effects of different doses oftoxicants, long-term effects andthe role of epigenetics, particular vulnerability at certain stages of development,notably the foetal stage and early childhood, and the effects of mixtures. Prof.Robert Barouki, Université Paris Descartes - France explained how these newdata have an impact on regulations and public health.
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