Annual-Report-2019

PHYSIOLOGIE DE LA REPRODUCTION ET DES
COMPORTEMENTS (PRC) - UMR 085 - CENTRE INRAE VAL DE
LOIRE, UNIVERSITÉ DE TOURS, CNRS, INSTITUT FRANÇAIS DU
CHEVAL ET DE L’ÉQUITATION
The Reproductive Physiology and Behaviours Laboratory is affiliated to INRAE, CNRS, University of Tours and IFCE. The
Biology and Bioinformatics of Signalling Systems (BIOS) group uses systems biology approaches, including mathematical
modelling and bioinformatics, to decipher G protein-coupled receptors (GPCR)-induced signalling and develops new
pharmacological strategies targeting these receptors. A particular emphasis has long been put on the receptors for
follicle stimulating and luteinizing hormones (FSHR and LHR) that are centrally involved in the control of reproduction.
Capitalizing on the dynamics initiated in The Centre-Val de Loire region in the framework of the MabImprove LabEx
and the ARD 2020 “Biopharmaceuticals”, the BIOS group is currently developing GPCR-specific antibody fragments
displaying pharmacological efficacy in vivo.
TRANSPLANTATION, IMMUNOLOGIE ET INFLAMMATION (T2I)
EA 4245 - UNIVERSITÉ DE TOURS
The Transplantation, Immunology and Inflammation T2I - EA 4245 research team is directed by Prof. Christophe Baron
and is based at the Faculty of medicine of the University of Tours. The team is imbedded in the Labex MabImprove.
Research axis focuses on the study of the immuno-inflammatory response in organ transplantation and during ischemia
reperfusion, the identification of biomarkers of organ dysfunction (tissue injury, rejection, relapse) and the development
of new therapeutic strategies (antibodies and pharmacological agents) to prevent tissue damage. The unit is interested
in understanding the interactions between stressed tissue cells (cardiac cells, normal or cancerous epithelial cells)
and immune cells for the modulation of immuno-inflammatory responses in hypoxia/ischemia and in developing novel
strategies using pharmacological agents and antibodies with immuno-modulatory properties targeting ion channels
and purinergic receptors.
Life & Health Sciences 2019
Life & Health Sciences 2019
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