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Thoracic Imaging 2003 - Society of Thoracic Radiology

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MONDAY<br />

108<br />

7.5 mm) than the inferior pulmonary veins (14.0 ± 6.2 mm).<br />

There is no significant difference between the average diameters<br />

<strong>of</strong> the right and left pulmonary vein ostia, (mean <strong>of</strong> 18.0 ± 3.7<br />

mm). The superior pulmonary veins are typically larger than the<br />

inferior pulmonary veins [3, 16, 17]. The most common<br />

anatomic variant, the right middle pulmonary vein, has an ostial<br />

diameter significantly smaller than the other pulmonary veins<br />

(9.9 ± 1.9 mm). When present, a common left pulmonary vein<br />

trunk will have a diameter significantly larger than the other<br />

pulmonary veins (32.5 ± 0.5 mm). In studies by Scharf, Sneider,<br />

et al., and Tsau, Wu, et al., the pulmonary veins in patients with<br />

atrial fibrillation were significantly larger than those <strong>of</strong> patients<br />

without atrial fibrillation. There was no difference between the<br />

size <strong>of</strong> veins in patients with paroxysmal versus persistent fibrillation.<br />

Atrial fibrillation patients also had a left atrial surface<br />

area greater than normal individuals [10, 11].<br />

EFFECTS OF ABLATION ON OSTIAL DIAMETER<br />

Several studies have shown that 40 – 100% <strong>of</strong> patients will<br />

develop some degree <strong>of</strong> pulmonary vein stenosis following RF<br />

ablation [6, 11, 12]. The vast majority have less than 10% stenosis,<br />

and are completely asymptomatic with up to 68% luminal<br />

stenosis. Severe stenosis is very rare, and to date there have<br />

been only two reported cases <strong>of</strong> significant sequela from severely<br />

symptomatic veno-occlusive disease and hemorrhagic pulmonary<br />

venous infarction [7, 12].<br />

SUMMARY<br />

Radi<strong>of</strong>requency ablation <strong>of</strong> arrhythmogenic foci within the<br />

proximal veins has been repeatedly shown to be highly effective<br />

for the treatment <strong>of</strong> paroxysmal and persistent atrial fibrillation.<br />

Knowledge <strong>of</strong> the size and number <strong>of</strong> pulmonary veins is<br />

important in planning a successful ablation procedure, since as<br />

many as 20% <strong>of</strong> patients will display anatomic variations.<br />

<strong>Imaging</strong> with multi-row CT is an effective and rapid method<br />

providing this information. Although pulmonary venous stenosis<br />

is a frequent complication <strong>of</strong> RF ablation, it is most usually<br />

asymptomatic, even with stenosis <strong>of</strong> up to 68%. Complications<br />

from severe stenosis are extremely rare. CT imaging facilitates<br />

effective follow-up screening for pulmonary vein stenosis and<br />

assessment <strong>of</strong> severity and progression.<br />

REFERENCES<br />

1. Haissaguerre M, Jais P, Shah DC, et al. Spontaneous initiation<br />

<strong>of</strong> atrial fibrillation by ectopic beats originating in the pulmonary<br />

veins. N Engl J Med 1998;339:659-666<br />

2. Chen SA, Hsieh MH, Tai CT, et al. Initiation <strong>of</strong> atrial fibrillation<br />

by ectopic beats originating from the pulmonary veins: electrophysiological<br />

characteristics, pharmacological responses, and<br />

effects <strong>of</strong> radi<strong>of</strong>requency ablation. Circulation 1999;100:1879-<br />

1886<br />

3. Lin WS, Prakash VS, Tai CT, et al. Pulmonary vein morphology<br />

in patients with paroxysmal atrial fibrillation initiated by ectopic<br />

beats originating from the pulmonary veins: implications for<br />

catheter ablation. Circulation 2000;101:1274-1281<br />

4. Haissaguerre M, Jais P, Shah DC, et al. Electrophysiological<br />

end point for catheter ablation <strong>of</strong> atrial fibrillation initiated from<br />

multiple pulmonary venous foci. Circulation 2000;101:1409-<br />

1417<br />

5. Oral H, Knight BP, Tada H, et al. Pulmonary vein isolation for<br />

paroxysmal and persistent atrial fibrillation. Circulation<br />

2002;105:1077-1081<br />

6. Robbins IM, Colvin EV, Doyle TP, et al. Pulmonary vein stenosis<br />

after catheter ablation <strong>of</strong> atrial fibrillation. Circulation<br />

1998;98:1769-1775<br />

7. Scanavacca MI, Kajita LJ, Vieira M, Sosa EA. Pulmonary vein<br />

stenosis complicating catheter ablation <strong>of</strong> focal atrial fibrillation.<br />

J Cardiovasc Electrophysiol 2000;11:677-681<br />

8. Yu WC, Hsu TL, Tai CT, et al. Acquired pulmonary vein stenosis<br />

after radi<strong>of</strong>requency catheter ablation <strong>of</strong> paroxysmal atrial fibrillation.<br />

J Cardiovasc Electrophysiol 2001;12:887-892<br />

9. Seshadri N, Novaro GM, Prieto L, et al. Images in cardiovascular<br />

medicine. Pulmonary vein stenosis after catheter ablation<br />

<strong>of</strong> atrial arrhythmias. Circulation 2002;105:2571-2572<br />

10. Tsao HM, Wu MH, Yu WC, et al. Role <strong>of</strong> right middle pulmonary<br />

vein in patients with paroxysmal atrial fibrillation. J<br />

Cardiovasc Electrophysiol 2001;12:1353-1357<br />

11. Scharf C, Sneider MB, Case I, et al. Anatomy <strong>of</strong> the<br />

Pulmonary Veins in Patients With Atrial Fibrillation and Effects<br />

<strong>of</strong> Segmental Ostial Ablation Analyzed by Computed<br />

Tomography. J Cardiovasc Electrophysiol <strong>2003</strong>;In Press<br />

12. Ravenel JG, McAdams HP. Pulmonary venous infarction after<br />

radi<strong>of</strong>requency ablation for atrial fibrillation. AJR Am J<br />

Roentgenol 2002;178:664-666<br />

13. Jais P, Shah DC, Hocini M, Yamane T, Haissaguerre M,<br />

Clementy J. Radi<strong>of</strong>requency catheter ablation for atrial fibrillation.<br />

J Cardiovasc Electrophysiol 2000;11:758-761<br />

14. Lickfett LM, Calkins HG, Berger RD. Radi<strong>of</strong>requency Ablation<br />

for Atrial Fibrillation. 2002;4:295-306<br />

15. Oral H, Knight BP, Ozaydin M, et al. Segmental ostial ablation<br />

to isolate the pulmonary veins during atrial fibrillation: feasibility<br />

and mechanistic insights. Circulation 2002;106:1256-1262<br />

16. Nathan H, Eliakim M. The junction between the left atrium and<br />

the pulmonary veins. An anatomic study <strong>of</strong> human hearts.<br />

Circulation 1966;34:412-422<br />

17. Ho SY, Sanchez-Quintana D, Cabrera JA, Anderson RH.<br />

Anatomy <strong>of</strong> the left atrium: implications for radi<strong>of</strong>requency<br />

ablation <strong>of</strong> atrial fibrillation. J Cardiovasc Electrophysiol<br />

1999;10:1525-1533

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