EBV Conference 2008 Guangzhou - Baylor College of Medicine

170 (RegID: 1016)
Chin-Tarng Lin
Institution: Postgraduate Institute and Department of Pathology, College of Medicine, National Taiwan
University and Hospital, Taipei, Taiwan
e-mail: ctl@ntu.edu.tw
NASOPHARYNGEAL CARCINOMA (NPC): MOLECULAR PATHOGENESIS AND CLINICAL
INTERVENTION
Posterabstract:
For therapeutic intervention of NPC, we use the NPC cell lines to select a 12-mer specific peptide which
can bind specifically to the surface of NPC cells by phage-displayed random peptide library. This peptide
has met several criteria for targeted drug delivery into a NPC solid tumor. In vitro experiment the peptide
can bind specifically to the cell surfaces of most NPC cell lines and biopsy specimens; the peptide-linked
liposome containing fluorescent substance is capable of binding to and translocation across cell
membranes; in vivo, this specific peptide can bind and accumulate in the xenograft in SCID mice, but not
in normal organs; similarly the peptide-linked liposome carried doxorubicin not only can cause marked
cytotoxicity of NPC cells in vitro, in vivo, it can also suppress markedly the xenograft growth in SCID
mice without systemic side effect; when the L-peptide is linked with iron oxide nanoparticles, the
L-peptide-iron oxide can be used for MR imaging analysis of NPC tumor site in vivo. In conclusion, the
novel peptide we identified can be used for targeted chemotherapy with high efficacy and without
systemic side effect and for MRI analysis of NPC tumor site in vivo. Application of this peptide-targeted
therapy against NPC may let this cancer becomes easier to be controlled.
EBV Conference 2008 Guangzhou
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