EBV Conference 2008 Guangzhou - Baylor College of Medicine

174 (RegID: 1069)
Ching Ching Ng
Institution: Institute of Biological Sciences, University of Malaya
e-mail: ngchingching2020@yahoo.com
SPLUNC1 POLYMORPHISMS ASSOCIATED WITH NASOPHARYNGEAL CARCINOMA
SUSCEPTIBILITY IN MALAYSIAN CHINESE
Ng Ching Ching1,2, Yew Poh Yin1,2, Taisei Mushiroda3, Gopala Krishnan5, Yusuke Nakamura1,4
Posterabstract:
Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck region that occurs in the
nasopharynx tissue. NPC rarely occurs in most parts of the world, but it is common in China, Taiwan and
Southeast Asia including Thailand, Vietnam, Indonesia, Malaysia and Singapore. In West Malaysia, NPC
is the second and twelfth most common cancer among men and women respectively. The fact that
Malaysian Chinese shows higher incidence of NPC compared to other races revealed that genetic
susceptibility might be a crucial etiologic factor. In this study, we aimed to investigate the association of
SPLUNC1 genes with NPC in Malaysian Chinese. We conducted a case-control study by genotyping eight
tagged-single nucleotide polymorphisms (tSNPs) within this gene in 159 NPC cases and 408 controls
subjects. Here, we reported that four tSNPs were significantly associated with NPC. Among these 4 tSNPs,
one was most significantly associated with NPC [p =0.0003, OR=2.00, 95% CI =1.38-2.89]. Hence our
result suggests that SPLUNC1 polymorphisms may contribute to the susceptibility to NPC.
EBV Conference 2008 Guangzhou
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