EBV Conference 2008 Guangzhou - Baylor College of Medicine

222 (RegID: 1591)
Xia Liu
Institution: Department of Microbiology,Medical College of Qingdao University
e-mail: qdliuxia@yahoo.com.cn
STUDY ON EPSTEIN-BARR VIRUS AND HUMAN HERPES VIRUS 6 INFECTION IN DRUP
ERUPTION PATIENTS
Liu Xia,Zhu Guizhi,Chen Guanzhi,Luo Bing
(1.Department of Microbiology,Medical College of Qingdao University,Shandong Qingdao 266021,
China;2.Department of Dermatology,the Second Affiliated Hospital of Medical Colledge Qingdao
University, Shangdong 266042,China;3.Department of Dermatology,the Affiliated Hospital of Medical
Colledge Qingdao University,Shangdong 26003,China)
Posterabstract:
Drug eruption,a drug-induced systemic reaction to certain drugs,is a kind of common emergency case in
departmrnt of dermatology. It has serious symtoms,associated with the following manifestations:high
fever over 38℃,lymphadenopathy,facial edema,marked leukocytosis with eosinophilia and atypical
lymphocytes,lymphocytopenia, liver and renal dysfunction,and low IgG level.However, the machanism
of drup eruption is not wellknown.Our experiment was to study the role of Epstein-Barr virus and Human
herpes virus 6 in drug eruption patients.EBV genome were tested in PBMC of 31 drup eruption patients
and normal control by PCR-Southern blotting.Our result suggested that the positive rate of EBV DNA in
drup eruption patients was higher than in normal control(P0.05).ELISA result showed that
the positive rate of EBV VCA-IgM in drup eruption patients was higher than the normal control
(P