EBV Conference 2008 Guangzhou - Baylor College of Medicine

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Yi-xin Zeng, Tiebang Kang
State Key Laboratory of Oncology in Southern China,
Sun Yat-Sen University Cancer Center, Guangzhou, China, 510060
e-mai : kangtb@mail.sysu.edu.cn
zengyix@mail.sysu.edu.cn
EPSTEIN-BARR VIRUS (EBV) AND NASOPHARYNGEAL CARCINOMA (NPC)
Yin-xin Zeng and Tiebang Kang
State Key Laboratory of Oncology in Southern China,
Sun Yat-Sen University Cancer Center, Guangzhou, China, 510060.
Abstract:
Infection with Epstein-Barr virus (EBV) is considered as the major contributor for Nasopharyngeal carcinoma
(NPC), a disease with a remarkable geographic and ethnic distribution worldwide. We have previously reported
genomic sequence of EBV GD1 strain from a NPC patient in Canton, one of the NPC endemic regions (Zeng
MS et. al., JVI 2005). In this conference, we will discuss the new progresses made in our laboratory: 1) the
profile of EBV strains in Cantonese based upon the sequence variations in LMP1 carboxyl-terminus, showing
that China1 (Ch1) might be the susceptible strain for invading host in Canton; 2) 155849A in RPMS1 of EBV
may represent a specific EBV subtype in the NPC endemic region, and could serve as a valuable indicator for a
high risk of NPC in southern China. 3) IgA- and IgG-gp78 are novel biomarkers for NPC diagnosis by screening
EBV serological parameters based on xMAP technology.
Key words: Epstein-Barr virus, nasopharyngeal carcinoma, LMP1; China 1, RPMS1, gp78, xMAP technology
EBV Conference 2008 Guangzhou
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