Corynebacterium glutamicum - JUWEL - Forschungszentrum Jülich

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OTR, CTR 0.06 0.04 0.02 0 0 10 20 30 time [h] (a) OTR and CTR in the second RAMOS experiment in flasks with filling volume of 10 mL. OTR, CTR 0.06 0.04 0.02 0 0 10 20 30 time [h] (c) OTR and CTR in the second RAMOS experiment in flasks with filling volume of 20 mL. OTR, CTR 0.06 0.04 0.02 0 0 10 20 30 time [h] (b) OTR and CTR in the second RAMOS experiment in flasks with filling volume of 15 mL. OTR, CTR 0.06 0.04 0.02 0 0 10 20 30 time [h] (d) OTR and CTR in the second RAMOS experiment in flasks with filling volume of 30 mL. Figure C.8.: OTR as dotted lines in mol.L −1 .h −1 and CTR as solid lines in mol.L −1 .h −1 in the second RAMOS experiment. 147
C. The Influence of the Oxygen Supply. val [mM] 50 40 30 20 10 0 0 10 20 30 40 time [h] (a) L-Valine (val)concentrations in the second RAMOS experiment. gly [ µ M] 1500 1000 500 0 0 10 20 30 40 time [h] (c) L-Glycine (gly) concentrations in the second RAMOS experiment. ala [µM] 3000 2000 1000 0 0 10 20 30 40 time [h] (b) L-Alanine (ala) concentrations in the second RAMOS experiment. leu [mM] 1500 1000 500 0 0 10 20 30 40 time [h] (d) L-Leucine (leu) concentrations in the second RAMOS experiment. Figure C.9.: Concentrations of several amino acids in the second RAMOS experiment. Concentrations in flasks with 10 mL volume as +, in 15 mL as ×, in20mL as � and in 30 mL as ♦. Lines are a visual aid. The final concentrations are connected to markers indicating the final concentrations in the flasks in the RAMOS device. 148
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Lebenswissenschaften Life Sciences
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Forschungszentrum Jülich GmbH Inst
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’Therefore, mathematical modeling
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Contents 3.4. Application: L-Valine
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Contents 4
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1. Introduction need for improved m
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2. Theory In a batch process, all s
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2. Theory 1997; Goncalves et al., 2
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2. Theory For batch fermentations,
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2. Theory with Yps being the yield
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2. Theory Inhibition Some catalytic
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2. Theory The method of least squar
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2. Theory evaluation can be made by
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2. Theory We define the measured or
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2. Theory build in the model. An ob
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2. Theory nations, the researcher i
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2. Theory W = J · Covθ · J T (2.
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2. Theory arg max ξ � m� m�
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2. Theory with all measured values
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2. Theory which can be estimated us
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2. Theory One option to account for
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2. Theory θ 2 $θ 2 0 area ≅ det
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2. Theory designed using a paramete
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2. Theory proteome14 (Hermann et al
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2. Theory 44
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3. Dynamic Modeling Framework itera
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3. Dynamic Modeling Framework 3.3.
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3. Dynamic Modeling Framework 3.3.3
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3. Dynamic Modeling Framework 52 du
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3. Dynamic Modeling Framework the c
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3. Dynamic Modeling Framework For d
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3. Dynamic Modeling Framework subse
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3. Dynamic Modeling Framework 60
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4. Simulative Comparison of Model D
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5. L-Valine Production Process Deve
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Page 103 and 104: 5. L-Valine Production Process Deve
Page 140 and 141: A. Nomenclature Table A.1.: Symbols
Page 142 and 143: Table A.1.: Symbols and Abbreviatio
Page 144 and 145: Table A.1.: Symbols and Abbreviatio
Page 146 and 147: B. Ratio between OD600 and Dry Weig
Page 148 and 149: C. The Influence of the Oxygen Supp
Page 150 and 151: The measurements of amino acids and
Page 152 and 153: kiv [mM] lac [mM] 15 10 5 0 0 10 20
Page 156 and 157: DO properly at a low value in dynam
Page 158 and 159: D. Dilution for Measurement of Amin
Page 160 and 161: E. Models used in the First Model D
Page 162 and 163: Model 1.6 Model 1.6 is similar to m
Page 164 and 165: Table E.1: Model Parameters of the
Page 166 and 167: Table E.2: Model Parameters of the
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Page 170 and 171: Model 2.2 Model 2.2 is similar to m
Page 172 and 173: Table F.1.: Model Parameters of the
Page 174 and 175: Table F.2.: Estimated Lag-Times of
Page 176 and 177: Table F.3: Model Parameters of the
Page 178 and 179: Table F.4.: Estimated Lag-Times of
Page 180 and 181: G. Alternative Off-line Optimized P
Page 182 and 183: G.2. Overall Yield of Product on Su
Page 184 and 185: Summary Fast development of product
Page 186 and 187: Zusammenfassung Es ist wichtig, die
Page 188 and 189: Acknowledgements This thesis result
Page 190 and 191: Bibliography K. Akashi, H. Shibai,
Page 192 and 193: Bibliography A. Bodalo-Santoyo, J.L
Page 194 and 195: Bibliography A.J. Cooper, J.Z. Gino
Page 196 and 197: Bibliography A.G. Fredrickson, R.D.
Page 198 and 199: Bibliography W.G. Hunter and A.M. R
Page 200 and 201: Bibliography A.C. McHardy, A. Tauch
Page 202 and 203: Bibliography E. Radmacher, A. Vaits
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Bibliography K.J. Versyck, J.E. Cla
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Corynebacterium glutamicum - JUWEL - Forschungszentrum Jülich

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