Corynebacterium glutamicum - JUWEL - Forschungszentrum Jülich

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Feed [L/h] C X [g/L] C S [mM] C P [mM] 0.04 0.02 4.2. First Case: Fermentation 0 0 10 20 30 40 50 time [h] 50 25 (a) Feedrate in L/h of a 3889 mM substrate solution. 0 0 400 10 20 30 40 50 200 0 0 1000 10 20 30 40 50 500 0 0 10 20 30 40 50 time [h] (b) Expected concentrations of biomass (CX), substrate (CS) and product (CP ) according to model Ferm1 with closed markers and according to Ferm2 with open markers. Criterion 400 200 0 0 10 20 30 40 50 time [h] (c) Contribution to the HR criterion, of the suggested measurements of biomass as ◦, substrate as � and product as ♦ Markers show the values, lines are a visual aid. Figure 4.6.: Designed experiment according to the HR criterion. Initial substrate concentration: 55 mM. 71
4. Simulative Comparison of Model Discriminating Design Criteria Feed [L/h] C X [g/L] C S [mM] C P [mM] 0.06 0.03 0 0 10 20 30 40 50 time [h] 50 25 (a) Feedrate in L/h of a 3889 mM substrate solution. 0 0 200 10 20 30 40 50 100 0 0 2000 10 20 30 40 50 1000 0 0 10 20 30 40 50 time [h] (b) Expected concentrations of biomass (CX), substrate (CS) and product (CP ) according to model Ferm1 with closed markers and according to Ferm2 with open markers. Criterion 600 300 0 0 10 20 30 40 50 time [h] (c) Contribution of the suggested measurements to the ND criterion. Contribution of the difference in measured values as ◦ and a part directed by the shape of the responses as �. Markers show the values, lines are a visual aid. Figure 4.7.: Designed experiment according to the ND criterion. Initial substrate concentration: 55 mM. 72
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Lebenswissenschaften Life Sciences
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Forschungszentrum Jülich GmbH Inst
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’Therefore, mathematical modeling
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Contents 3.4. Application: L-Valine
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Contents 4
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1. Introduction need for improved m
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2. Theory In a batch process, all s
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2. Theory 1997; Goncalves et al., 2
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2. Theory For batch fermentations,
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2. Theory with Yps being the yield
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2. Theory Inhibition Some catalytic
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2. Theory The method of least squar
Page 27 and 28: 2. Theory evaluation can be made by
Page 29 and 30: 2. Theory We define the measured or
Page 31 and 32: 2. Theory build in the model. An ob
Page 33 and 34: 2. Theory nations, the researcher i
Page 35 and 36: 2. Theory W = J · Covθ · J T (2.
Page 37 and 38: 2. Theory arg max ξ � m� m�
Page 39 and 40: 2. Theory with all measured values
Page 41 and 42: 2. Theory which can be estimated us
Page 43 and 44: 2. Theory One option to account for
Page 45 and 46: 2. Theory θ 2 $θ 2 0 area ≅ det
Page 47 and 48: 2. Theory designed using a paramete
Page 49 and 50: 2. Theory proteome14 (Hermann et al
Page 51 and 52: 2. Theory 44
Page 53 and 54: 3. Dynamic Modeling Framework itera
Page 55 and 56: 3. Dynamic Modeling Framework 3.3.
Page 57 and 58: 3. Dynamic Modeling Framework 3.3.3
Page 59 and 60: 3. Dynamic Modeling Framework 52 du
Page 61 and 62: 3. Dynamic Modeling Framework the c
Page 63 and 64: 3. Dynamic Modeling Framework For d
Page 65 and 66: 3. Dynamic Modeling Framework subse
Page 67 and 68: 3. Dynamic Modeling Framework 60
Page 69 and 70: 4. Simulative Comparison of Model D
Page 77: 4. Simulative Comparison of Model D
Page 95 and 96: 5. L-Valine Production Process Deve
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5. L-Valine Production Process Deve
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A. Nomenclature Table A.1.: Symbols
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Table A.1.: Symbols and Abbreviatio
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Table A.1.: Symbols and Abbreviatio
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B. Ratio between OD600 and Dry Weig
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C. The Influence of the Oxygen Supp
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The measurements of amino acids and
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kiv [mM] lac [mM] 15 10 5 0 0 10 20
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OTR, CTR 0.06 0.04 0.02 0 0 10 20 3
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DO properly at a low value in dynam
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D. Dilution for Measurement of Amin
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E. Models used in the First Model D
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Model 1.6 Model 1.6 is similar to m
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Table E.1: Model Parameters of the
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Table E.2: Model Parameters of the
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161
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Model 2.2 Model 2.2 is similar to m
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Table F.1.: Model Parameters of the
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Table F.2.: Estimated Lag-Times of
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Table F.3: Model Parameters of the
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Table F.4.: Estimated Lag-Times of
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G. Alternative Off-line Optimized P
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G.2. Overall Yield of Product on Su
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Summary Fast development of product
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Zusammenfassung Es ist wichtig, die
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Acknowledgements This thesis result
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Bibliography K. Akashi, H. Shibai,
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Bibliography A. Bodalo-Santoyo, J.L
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Bibliography A.J. Cooper, J.Z. Gino
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Bibliography A.G. Fredrickson, R.D.
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Bibliography W.G. Hunter and A.M. R
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Bibliography A.C. McHardy, A. Tauch
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Bibliography E. Radmacher, A. Vaits
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Bibliography K.J. Versyck, J.E. Cla
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Corynebacterium glutamicum - JUWEL - Forschungszentrum Jülich

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