Physics And Chemistry Basis Of Biotechnology - De Cuyper - tiera.ru

Radioactive microspheres for medical applications
Table 1: Medical applications of microspheres
Mechanism Application (Examples) Microsphere Matrix Ref.
(Examples)
Controlled drug Release of proteins, PLA, PLGA, chitosan, [6]
delivery after local hormones and peptides polycyanoacrylate,
application over extended times polyanhydride
Oral drug delivery Gene therapy with DNA PLGA, styrene, [7]
of easily degraded plasmids; delivery of polymethylmethacrylate
drugs insulin, LHRH
Vaccine delivery Hepatitis, influenza, PLGA, chitosan [8,9]
pertussis, ricin toxoid,
diphteria toxoid; birth
control
Drug targeting Passive targeting of leaky Any biocompatible
after intravenous / tumour vessels, active material; liposomes or
intra-arterial targeting of tumour cell erythrocytes
application antigens, magnetic
targeting with
microspheres
Drug delivery Tumour targeting with PLA, PLGA, starch [10,11]
without toxic side doxorubicin, treatment of cyanoacrylates, etc.;
effects Leishmaniasis (PEG-) liposomes
Specific cell Stem cell extraction, bone Magnetic polystyrene [12]
labelling marrow purging microspheres
Affinity Isolation of antibodies in Polymer resins such as [ 13]
chromatography immunology, cell Agarose-polyacrolein,
separation, toxin Sephadex (polymer
extraction supports)
Adsorption of Haemoperfusion Agarose-PA 7 Sepharose, [ 14]
harmful substances activated carbon,
from blood polyvinyl alcohol,
polyacrylamide
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