Radiation-induced bioradicals: technologies and research Herak, J. N., Sankovic, K., and Hutterman, J. 1994. Thiocytosine as radiation energy trap in a single-crystal of cytosine hydrochloride. Int. J. Radiat. Biol. 66:3-9. Herak, J. N., Sankovic, K., Krilov, D., Jaksic, M., and Huttermann, J. 1997. Radiation energy transfer and trapping in single crystals of semihydrate and hydrochloride of 5-methylcytosine doped with 5methylthiocytosine - An EPR study. Radiat. Phys. Chem. 50:141-148. Herak, J. N., Sankovic, K., Krilov, D., and Huttermann, J. 1999. An EPR study of the transfer and trapping of holes produced by radiation in guanine(thi0guanine) hydrochloride single crystals. Radiat. Res. 151:319-324. Hill, M. A. 1999. Radiation damage to DNA: The importance of track st<strong>ru</strong>cture. Radiat. Meas. 31: 15-23. Hohenberg, P., and Kohn, W. 1964. XXX. Phys. Rev. B 136:864. Hole, E. O., Sagstuen, E., Nelson, W. H., and Close, D. M. 1989. Free-radical formation in single-crystals of 2'-deoxyguanosine 5'-monophosphate, and guanine hydrobromide monohydrate after X-irradiation at 10 K and 65 K - An ESR, ENDOR and FSE study. Free Radical Res. Commun. 6:87-90. Hole, E. O., Sagstuen, E., Nelson, W. H., and Close, D. M. 1991a. Primary reduction and oxidation of thymine derivatives - ESR/ENDOR of thymidine and I-methylthymidine X-irradiated at 10 K. J. Phys. Chem. 95:1494-1503. Hole, E. O., Sagstuen, E., Nelson, W. H., and Close, D. M. 1991b. Environmental effects on primary radical formation in guanine - solid-state ESR and ENDOR of guanine hydrobromide monohydrate. Radiat. Res. 125:119-128. Hole, E. O., Nelson, W. H., Sagstuen, E., and Close, D. M. 1992a. Free-radical formation in X-irradiated anhydrous crystals of inosine studied by EPR and ENDOR spectroscopy. Radiat. Res. 130:148-159. Hole, E. O., Sagstuen, E., Nelson, W. H., and Close, D. M. 1992b. The st<strong>ru</strong>cture of the guanine cation - ESR/ENDOR of cyclic guanosine-monophosphate single-crystals after X-irradiation at 10 K. Radiat. Res. 129:1-10. Hole, E. O., Nelson, W. H., Sagstuen, E., and Close, D. M. 1992c. Free-radical formation in single-crystals of 2'-deoxyguanosine 5'-monophosphate tetrahydrate disodium salt - An EPR ENDOR study. Radiat. Res. 129:119-138. Hole, E. O., Sagstuen, E., Nelson, W. H., and Close, D. M. 1995. Free-radical formation in single-crystals of 9-methyladenine X-irradiated at 10K - An electron-paramagnetic-resonance and electron-nuclear double-resonance study. Radiat. Res. 144:258-265. Hole, E. O., Nelson, W. H., Sagstuen, E., and Close, D. M. 1998. Electron paramagnetic resonance and electron nuclear double resonance studies of X-irradiated crystals of cytosine hydrochloride. Part I: Free radical formation at 10 K after high radiation doses. Radiat. Res. 149:109-119. Huang, W. D., Han, J. W., Wang, X. Q., Yu, 2. L., and Zhang, Y. H. 1998. keV ion irradiation of solid glycine: an EPR study. Nucl. Inst<strong>ru</strong>m. Meth. Phys. Res. B 140 :137-142. IAEA-Tecdoc-971, 1997. Sewage sludge and wastewater for use in agriculture IAEA -Tecdoc-1023. 1998. Radiation technology for conservation of the environment Ibrahim, R., Mondelaers, W., and <strong>De</strong>bergh, P. C. 1998. Effects of X-irradiation on adventitious bud regeneration from in vitro leaf explants of Rosa hybrida. Plant Cell Tissue Organ Cult. 54:37-44. Iliakis, G. 1991. The role of DNA double strand breaks in ionising radiation-induced killing of eukaryotic cells. Bioessays 13:641-648. Jacobs, G. P., and Wills, P. A. 1988. Recent developments in the radiation sterilisation of pharmaceuticals. Radiat. Phys. Chem. 31:685-691. Jacobs, G. P. 1995. A review of the effects of gamma-radiation on pharmaceutical materials. J. Biomater. Appl. 10:59-96. Jacobs, G. P. 1998. A review on the effects of ionising radiation on blood and blood components. Radiat. Phys. Chem. 5351 1-523. Jensen, F. 1999.Introduction to computational chemistry, John Wiley & Sons, Ltd. Kabiljo, Z., Sankovic, K., and Herak, J. N. 1990. ESR study of the thymine anion radical in a single-crystal of thymine monohydrate. Int. J. Radiat. Biol 58:439-447. Kaetsu, I. 1996. Biomedical materials, devices and d<strong>ru</strong>g delivery systems by radiation techniques. Radiat. Phys. Chem. 47:419-424. Kaetsu, I., Uchida, K., Shindo, H., Gomi, S., and Sutani, K. 1999. Intelligent type controlled release systems by radiation techniques. Radiihem. 55:193-201. 297
Philippe Lahorte and Wim Mondelaers Kim, H., Budzinski, E. E., and Box, H. C. 1989. The radiation-induced oxidation and reduction of guanine - Electron-spin-resonance electron nuclear double-resonance studies of irradiated guanosine cyclic monophosphate. J. Chem. Phys. 90:1448-1451. Kohn, W., and Sham, L. J. 1965. Self-consistent equations including exchange and correlation effects, Phys. Rev. A 140:1133-1138. Kohn, W., Becke, A. D., and Parr, R. G. 1996. <strong>De</strong>nsity functional theory of electronic st<strong>ru</strong>cture. J. Phys. Chem. 100:12974-12980. Koppen, G., Toncelli, L. M., Triest, L., and Verschaeve, L. 1999. The comet assay: a tool to study alteration of DNA integrity in developing plant leaves. Mech. Age. <strong>De</strong>v. 110: 13-24. Krzyminiewski, R., Pietrzak, J., and Konopka, R. 1990. An ESR study of the stable radical in a gammairradiated single crystal of 17-alpha-hydroxy-progesterone. J. Mol St<strong>ru</strong>ct. 240: 133-140. Krzyminiewski, R., Bernhard, W., and Mercer, K. 1995. Conversion of free-radicals upon annealing of Xirradiated single-crystal of cholets-4-ene-3-one. Radiat. Phys. Chem. 45: 883-888. Kubli-Garfias, C. 1998a. Ab initio comparative study of the electronic st<strong>ru</strong>cture of testosterone, epitestosterone and androstenedione. Theochem-J. Mol. St<strong>ru</strong>ct. 422:167-177. Kubli-Garfias, C., and Vazquez-Ramirez, R. 1998b. Ab initio calculations of the electronic st<strong>ru</strong>cture of glucocorticoids. Theochem-J. Mol. St<strong>ru</strong>ct. 454:267-275. Kubli-Garfias, C. 1998c. Comparative study of the electronic st<strong>ru</strong>cture of estradiol, epiestradiol and estrone by ab initio theory. Theochem-J. Mol. St<strong>ru</strong>ct. 452:17S-183. Kubli-Garfias, C., Vazquez, R., and Mendieta, J. 1998d. Austin Model 1 study of the effect of carbonyl and hydroxyl functional groups on the electronic st<strong>ru</strong>cture of androstane. Theochem-J Mol. St<strong>ru</strong>ct. 428: 189-194. Kubli-Garfias, C. 1998e. Ab initio study of the electronic st<strong>ru</strong>cture of progesterone and related progestins. Theochem-J. Mol. St<strong>ru</strong>ct. 425:171-179. Kubli-Garfias, C. 1999. Comparative study of the electronic st<strong>ru</strong>cture of pregnanolones by ab initio theory. Int. J. Quantum Chem. 71:433-440. Kumagai, J., Katoh, H., Kumada, T., Tanaka, A,, Tano, S., and Miyazaki, T. 2000. Strong resistance of Arabidopsis thaliana and Raphanus sativus seeds for ionising radiation as studied by ESR, ENDOR, ESE spectroscopy and germination measurement: Effect of long-lived and super-long-lived radicals. Rad. Phys. Chem. 57:75-83. Lahorte, P., <strong>De</strong> Proft, F., Vanhaelewyn, G., Masschaele, B., Cauwels, P., Callens, F., Geerlings, P., and Mondelaers, W. 1999a. <strong>De</strong>nsity functional calculations of hyperfine coupling constants in alaninederived radicals. J. Phys. Chem. A 103:6650-6657. Lahorte, P., <strong>De</strong> Proit, F., Callens, F., Geerlings, P., and Mondelaers, W. 1999b. A density functional study of hyperfine coupling constants in steroid radicals. J. Phys. Chem. A 103:11130-11135. Lahorte, P., Mondelaers, W., <strong>De</strong> Frenne, D., Callens, F., Vanhaelewyn, G., Schacht, E., Van Calenberg, S., Van Cleemput, O., and Huyghebaert, A. 1999c. Applied radiation research around a 15 MeV highaverage-power linac. Radiat. Phys. Chem. 55:761-765. Langer-Safer, P. R., Fitz, L. J., Whitley, M. Z., Wood, C. R., and Beier, D. R. 1997. Strategies for the application of functional genomics technology to biopharmaceutical d<strong>ru</strong>g discovery. D<strong>ru</strong>g <strong>De</strong>velop. Res. 41:173-179. Lardon, A,, Georgiev, S., Aghmir, A,, Le Merrer, G., and Neg<strong>ru</strong>tiu, I. 1999. Sexual dimorphism in white campion: Complex control of carpel number is revealed by Y chromosome deletions. Genetics 151:1173-1185. Lassmann, G., Eriksson, L. A,, Himo, F., Lendzian, F., and Lubitz, W. 1999. Electronic st<strong>ru</strong>cture of a transient histidine radical in liquid aqueous solution: EPR continuous-flow studies and density functional calculations. J. Phys. Chem. A 103:1283-1290. Lett, J. T. 1994.The renaissance in basic cellular radiobiology and its significance for radiation therapy181- 223. Levine, I. N.1991 .Quantum chemistry4th: Lin, W. Z., Tu, T. C., Dong, J. R., Zhang, J. S., and Lin, N. Y. 1998. ESR studies of gamma-irradiated histone octamer and the histone H3. Radiat. Phys. Chem. 53:651-655. Luo, N., Litvin, A., and Osman, R. 1999. Theoretical studies of ribose and its radicals produced by hydrogen abstraction from ring carbons. J. Phys. Chem. A 103592-600. Mader, K. 1998. Pharmaceutical applications of in vivo EPR. Phys. Med. Biol. 43:1931-1935. 298
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PHYSICS AND CHEMISTRY BASIS OF BIOT
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Physics and Chemistry Basis of Biot
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EDITORS PREFACE At the end of the 2
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TABLE OF CONTENTS EDITORS PREFACE .
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4.3. Expression and functionality .
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2 . Magnetically labelled antibodie
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6.1. Instrumental characterisation
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BIOMIMETIC MATERIALS SYNTHESIS Abst
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Biomimetic materials synthesis cont
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Biomimetic materials synthesis 3. I
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Biomimetic materials synthesis The
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Biomimetic materials synthesis 3.2.
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Biomimetic materials synthesis 3.5.
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Biomimetic materials synthesis In t
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Biomimetic materials synthesis The
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Biomimetic materials synthesis Othe
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Biomimetic materials synthesis on s
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Biomimetic materials synthesis form
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Biomimetic materials synthesis poly
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Biomimetic materials synthesis anal
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Biomimetic materials synthesis Figu
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Biomimetic materials synthesis Sinc
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Biomimetic materials synthesis inte
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Biomimetic materials synthesis 42.
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Biomimetic materials synthesis 88.
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Biomimetic materials synthesis 136.
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DENDRIMERS: Chemical principles and
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Dendrimers: Chemical principles and
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Dendrimers: Chemical principles and
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Dendrimers: Chemical principles and
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Dendrimers: Chemical principles and
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Dendrimers: Chemical principles and
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RATIONAL DESIGN OF P450 ENZYMES FOR
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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Rational design of P450 enzymes for
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AMPEROMETRIC ENZYME-BASED BIOSENSOR
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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Amperometric enzyme-based biosensor
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SUPPORTED LIPID MEMBRANES FOR RECON
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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Supported lipid membranes for recon
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FUNCTIONAL STRUCTURE OF THE SECRETI
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Functional structure of the secreti
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Functional structure of the secreti
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Functional structure of the secreti
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Functional structure of the secreti
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COLD-ADAPTED ENZYMES D. GEORLETTE,
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Cold-adapted enzymes enzyme activit
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Cold-adapted enzymes their high spe
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Cold-adapted enzymes flexibility of
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Cold-adapted enzymes Some recent wo
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Cold-adapted enzymes Figure 2. Acti
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Cold-adapted enzymes is not complet
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Cold-adapted enzymes 16. Gilichinsk
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Cold-adapted enzymes 58. Rina, M.,
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Cold-adapted enzymes 101. Yip, K. S
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MOLECULAR AND CELLULAR MAGNETIC RES
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Molecular and cellular magnetic res
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Molecular and cellular magnetic res
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Molecular and cellular magnetic res
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Molecular and cellular magnetic res
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Molecular and cellular magnetic res
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Molecular and cellular magnetic res
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Molecular and cellular magnetic res
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RADIOACTIVE MICROSPHERES FOR MEDICA
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Radioactive microspheres for medica
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Radioactive microspheres for medica
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Radioactive microspheres for medica
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Radioactive microspheres for medica
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Radioactive microspheres for medica
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Radioactive microspheres for medica
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