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Principios de Patología

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10 <strong>Patología</strong> general<br />

Glc<br />

Gal<br />

PROCOLÁGENA<br />

Gal<br />

(Man)n<br />

GlcNac<br />

PROPÉPTIDO<br />

N-TERMINAL<br />

(15 nm)<br />

PROCOLÁGENA<br />

(300 nm)<br />

PROPÉPTIDO<br />

N-TERMINAL<br />

(10 nm)<br />

(Man)n<br />

GlcNac<br />

(2.0 nm)<br />

Glc<br />

Gal<br />

Gal<br />

(10 nm)<br />

Dominio<br />

globular<br />

Dominio triple<br />

helicoidal<br />

Dominio<br />

no triple<br />

helicoidal<br />

Dominio<br />

no triple<br />

helicoidal<br />

Dominio triple<br />

helicoidal<br />

(1.0 nm)<br />

Dominio<br />

no triple<br />

helicoidal<br />

FIGURA 2-2. Esquema <strong>de</strong> la molécula <strong>de</strong> procolágena y <strong>de</strong> las modificaciones que la transforman en una molécula <strong>de</strong> colágena insoluble. (Tomado <strong>de</strong> Procop DJ y cols. New Eng J. Med.<br />

301: 13, 77, 1979.)

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