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Principios de Patología

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C10 <strong>Patología</strong> <strong>de</strong>l aparato digestivo 213<br />

Epitelio normal<br />

Pérdida o mutación en el locus APC<br />

(cromosoma 5q)<br />

Epitelio hiperproliferativo<br />

Hipometilación <strong>de</strong>l ADN<br />

A<strong>de</strong>noma temprano<br />

Mutación <strong>de</strong>l gen ras (cromosoma 12p)<br />

A<strong>de</strong>noma intermedio<br />

Pérdida <strong>de</strong>l gen DCC (cromosoma 18q)<br />

A<strong>de</strong>noma tardío<br />

Pérdida <strong>de</strong>l gen p53 (cromosoma 17p)<br />

CARCINOMA<br />

FIGURA 10-35. Mo<strong>de</strong>lo molecular <strong>de</strong> la evolución <strong>de</strong>l cáncer colo-rectal (Fearon y<br />

Vogelstein).

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