Diabète Instable - Faculté de médecine de Montpellier
Diabète Instable - Faculté de médecine de Montpellier
Diabète Instable - Faculté de médecine de Montpellier
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<strong>Diabète</strong> <strong>Instable</strong>:<br />
Comment le comprendre et l’Améliorer ?<br />
Pickup & Sutton, Diabet Med, 2008<br />
Disparition <strong>de</strong> la Relation HbA1c –<br />
Hypoglycémies Sévères du DCCT sous<br />
Traitement par Pompe<br />
ate of severe hypoglycaemia<br />
(per 100 patient-years)<br />
Ra<br />
120<br />
100<br />
80<br />
60<br />
DCCT<br />
<br />
• Bo<strong>de</strong> BW 1996 [11] [2]<br />
Melki V 1998 [15] [3]<br />
Retnakaran R 2004 [22] [4]<br />
Doyle EA 2004 [5] [34]<br />
40<br />
•<br />
•<br />
20<br />
•<br />
•<br />
<br />
<br />
0<br />
<br />
5.0 6.0 7.0 8.0 9.0 10.0<br />
HbA 1c (%)<br />
Effectiveness of CSII vs. MDI in Type 2 Patients<br />
with Conventional Insulin Regimen Failure<br />
HbA1c<br />
• Cross-over randomized study 9<br />
(%)<br />
(12 weeks x 2)<br />
• 6-point daily SMBG<br />
8,5<br />
• CSII: all lowered<br />
• MDI: only lowered at morning<br />
8<br />
• AUC hyperglycemia<br />
• CSII: reduced by 73% (p
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